{"id":"W4410604017","doi":"10.1038/s41594-025-01532-6","title":"Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual","year":2025,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Malaria Research and Control","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Institutes of Health","keywords":"Epitope; Monoclonal antibody; Biology; Plasmodium falciparum; Virology; Antibody; Conformational epitope; Epitope mapping; Computational biology; Malaria; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319398,0.0003543539,0.0007207038,0.0004316847,0.00007689051,0.00002796307,0.0003439082,0.0006894838,0.0001536903],"category_scores_gemma":[0.0002434167,0.0002436369,0.000145008,0.0005201699,0.0002660471,0.00007364888,0.0001493898,0.001400839,0.000001238488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008621294,"about_ca_system_score_gemma":0.0002651341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003093407,"about_ca_topic_score_gemma":0.0002424774,"domain_scores_codex":[0.997764,0.0002642004,0.0004908555,0.0005794473,0.0003759343,0.0005255623],"domain_scores_gemma":[0.9988622,0.00008407079,0.000184008,0.0003814861,0.0003653644,0.0001228536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006317191,0.0000259777,0.02834108,0.00006747789,0.0008464107,0.0001735611,0.0001336408,0.00004654048,0.9447968,0.009301911,0.0001157326,0.009833679],"study_design_scores_gemma":[0.008967237,0.001349219,0.9374614,0.0001313521,0.0002109734,0.0001206604,0.0001838004,0.006092645,0.04008513,0.004938931,0.0001004046,0.0003582506],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912631,0.0023147,0.0006886613,0.004251261,0.0001718425,0.0008301567,0.0002320078,0.0000447352,0.0002035366],"genre_scores_gemma":[0.9913353,0.00001851661,0.004871237,0.00102864,0.00006894289,0.00001524271,0.002615429,0.00001822627,0.00002841446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9091203,"threshold_uncertainty_score":0.9935225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008805294303756126,"score_gpt":0.3075090623709972,"score_spread":0.298703768067241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}