{"id":"W4410605560","doi":"10.1177/13872877251344325","title":"Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants","year":2025,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Wellcome Trust","keywords":"Default mode network; Posterior cortical atrophy; Neuroscience; Disease; Cognition; Atrophy; Hippocampus; Prefrontal cortex; Resting state fMRI; Alzheimer's disease; Psychology; Posterior cingulate; Medicine; Pathology; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873155,0.0003912333,0.0002050325,0.0006472782,0.0002023844,0.000325069,0.0002191564,0.0002513039,0.0007956348],"category_scores_gemma":[0.0008730848,0.0001369936,0.0002143661,0.0003011175,0.0003677354,0.0003240921,0.0002526681,0.0001938746,0.0000357973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002383964,"about_ca_system_score_gemma":0.0001185259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003817536,"about_ca_topic_score_gemma":0.006193128,"domain_scores_codex":[0.9999225,0.0000223163,0.000006591769,0.00002994773,0.000008385791,0.00001030662],"domain_scores_gemma":[0.9997113,0.00009047671,0.000134255,0.0000210539,0.00001602981,0.00002669956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00124437,0.0001357249,0.9167921,0.0001688285,0.0007315645,0.001608335,0.001510518,0.002593676,0.04709647,0.002558524,0.0003524213,0.02520754],"study_design_scores_gemma":[0.00001124756,0.0000925756,0.9949585,0.00001262363,0.00006236821,0.0006541554,0.0001347424,0.001644004,0.0006291437,0.001678752,0.000117055,0.000004889576],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998654,0.0003673851,0.0006988809,0.0000238479,0.000002123362,0.000005060909,0.00008175812,0.000005458075,0.0001614147],"genre_scores_gemma":[0.9992307,0.000130459,0.0004776302,0.000008888192,0.000003123625,0.000005341489,0.0000769309,0.000001694907,0.00006513499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003817536,"threshold_uncertainty_score":0.007590592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03295992443676922,"score_gpt":0.2868891454248792,"score_spread":0.25392922098811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}