{"id":"W4410606269","doi":"10.1016/j.jcyt.2025.05.007","title":"International Call for a 10-Year Moratorium on Heritable Human Genome Editing","year":2025,"lang":"en","type":"editorial","venue":"Cytotherapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"International Society for Cellular Therapy","funders":"","keywords":"Genome editing; Biology; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001436967,0.0002519532,0.0002193213,0.00006983963,0.00008243701,0.00006096836,0.0003540914,0.0005437161,0.00009110218],"category_scores_gemma":[0.0001292881,0.0002727374,0.0001527035,0.0000425165,0.00002217325,0.000001671147,0.00005234138,0.0001857757,0.000006745587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005126128,"about_ca_system_score_gemma":0.0001160949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008395984,"about_ca_topic_score_gemma":0.000009233468,"domain_scores_codex":[0.9988521,0.00001370084,0.0002150778,0.0004568943,0.0002070525,0.0002551572],"domain_scores_gemma":[0.9992982,0.00003560985,0.00007717973,0.0003292414,0.0002082496,0.00005152404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000861172,0.00003049171,0.000002878327,0.00005237649,0.0001357433,0.000001007799,0.00001504688,0.0001588445,0.1455261,0.00002320621,0.8537081,0.0002601341],"study_design_scores_gemma":[0.0008765815,0.0002968612,0.000006154665,0.00004398722,0.00001354455,2.382359e-7,0.0000109198,0.00001738491,0.02197767,0.00002050868,0.9764947,0.0002414803],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.001226363,0.001460931,0.01417566,0.0001765133,0.9682229,0.0007338009,0.001588673,0.00007293357,0.01234227],"genre_scores_gemma":[0.001205836,0.0004126388,0.001064301,0.0001173768,0.9557307,0.000185236,0.00386206,0.00009709723,0.03732479],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.1235484,"threshold_uncertainty_score":0.9999725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006191552544957316,"score_gpt":0.3168571893027143,"score_spread":0.310665636757757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}