{"id":"W4410614974","doi":"10.47248/chp2502020009","title":"Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Heterogeneity and Plasticity","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Prostate cancer; Transcription factor; Hierarchy; Prostate; Transcription (linguistics); Biology; Cancer; Oncology; Cancer research; Medicine; Internal medicine; Genetics; Political science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264849,0.0001097141,0.0001671605,0.0003472745,0.0002532735,0.0006383644,0.000154778,0.0002167384,0.001349714],"category_scores_gemma":[0.0001199498,0.0002072705,0.0001387243,0.0001952494,0.0003016298,0.0002633731,0.0003056839,0.0004006189,0.0004365416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004158052,"about_ca_system_score_gemma":0.0003137172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001491763,"about_ca_topic_score_gemma":0.003368509,"domain_scores_codex":[0.9998603,0.00001711672,0.000004636928,0.00004183097,0.00003511369,0.00004095997],"domain_scores_gemma":[0.9999413,0.000005922899,0.0000112635,0.000005545269,0.00001078585,0.00002528995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001521232,0.00001623011,0.008199862,0.00004542901,0.0000151306,0.0001413059,0.0001600043,0.000271029,0.9809282,0.002486064,0.0003432177,0.007241441],"study_design_scores_gemma":[0.00003958428,0.0004525149,0.3952368,0.00005158192,0.0001088302,0.002184458,0.001534044,0.006302266,0.5441507,0.003158759,0.04669926,0.00008111007],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827466,0.004587633,0.004622621,0.0002868528,0.00003810766,0.00001141104,0.000318789,0.0001769909,0.00721109],"genre_scores_gemma":[0.9967483,0.0007292101,0.0005686635,0.0000648226,0.000008609874,0.000003787646,0.0001488434,0.00001610169,0.001711645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491763,"threshold_uncertainty_score":0.004515231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03353884538747622,"score_gpt":0.333081068735769,"score_spread":0.2995422233482928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}