{"id":"W4410621601","doi":"10.1038/s41551-025-01381-0","title":"Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression","year":2025,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"Liver physiology and pathology","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ted Rogers Centre for Heart Research","funders":"National Natural Science Foundation of China","keywords":"Hepatic stellate cell; Liver fibrosis; Hepatic fibrosis; Fibrosis; Tension (geology); Chemistry; Pathology; Medicine; Cell biology; Biology; Materials science; Compression (physics); Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126947,0.0001272512,0.0002716804,0.0002319497,0.00003992193,0.000003357621,0.0000641041,0.0005705787,0.00004843172],"category_scores_gemma":[0.0001446099,0.00009758055,0.0000893741,0.000356181,0.00006516138,0.00003574031,0.00004636124,0.000496507,0.000006118581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003164265,"about_ca_system_score_gemma":0.00007238485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001282515,"about_ca_topic_score_gemma":9.779045e-7,"domain_scores_codex":[0.9991778,0.00002760024,0.0002241121,0.000209438,0.0001969324,0.0001641025],"domain_scores_gemma":[0.9994798,0.000139707,0.00005189789,0.0001320238,0.0001181485,0.00007840768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001281254,0.0001250274,0.0008851904,0.0003118106,0.00008549613,0.00003425625,0.00004473532,0.00003033761,0.9920939,0.0001165607,0.0009840352,0.005160557],"study_design_scores_gemma":[0.001877038,0.0007698966,0.1325355,0.001678066,0.0003215317,0.00006856809,0.00002117877,0.03545222,0.8183777,0.00008014499,0.008547871,0.0002702998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934044,0.001257846,0.00281078,0.0007371035,0.001316526,0.0002484927,0.000007399236,0.0001025621,0.0001148302],"genre_scores_gemma":[0.995271,0.00006396108,0.004117931,0.0001705476,0.0001447324,0.000008073591,0.00006633113,0.000009479614,0.0001479069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1737162,"threshold_uncertainty_score":0.4400826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004168296665147687,"score_gpt":0.2459367072174101,"score_spread":0.2417684105522624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}