{"id":"W4410628148","doi":"10.1158/0008-5472.can-24-0044","title":"Loss of SMARCA4 Leads to Intron Retention and Generation of Tumor-Associated Antigens in Small Cell Carcinoma of the Ovary, Hypercalcemic Type","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Baylor Scott and White Research Institute; Division of Cancer Prevention, National Cancer Institute","keywords":"Ovary; SMARCA4; Cancer research; Biology; Intron; Antigen; Internal medicine; Medicine; Gene; Immunology; Genetics; Epigenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023044,0.0002009944,0.0001626336,0.0004031828,0.0001705531,0.0002141845,0.0001716895,0.0002136914,0.001136537],"category_scores_gemma":[0.0002421255,0.000135269,0.0003200571,0.000244727,0.0002238326,0.000070193,0.0001536794,0.0003131515,0.0001811241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570741,"about_ca_system_score_gemma":0.0002321061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199988,"about_ca_topic_score_gemma":0.001698636,"domain_scores_codex":[0.9998755,0.00001392793,0.00001603859,0.00002239683,0.00004337753,0.00002858101],"domain_scores_gemma":[0.9998159,0.00003428342,0.0000533896,0.00002065311,0.00001207217,0.00006378756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002821832,0.00007298631,0.006450895,0.00002398666,0.00002266531,0.001353724,0.00003227715,0.000118815,0.9898999,0.000088394,0.0000799179,0.001574226],"study_design_scores_gemma":[0.0001395889,0.001135332,0.2068267,0.00001111138,0.0001050548,0.01261125,0.0002685903,0.005161197,0.7698913,0.000233293,0.003599703,0.00001687769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993361,0.0001163737,0.0002293551,0.00001917603,0.000005752914,0.00000711129,0.00008909069,0.00001494819,0.0001821722],"genre_scores_gemma":[0.9990013,0.00009127369,0.0001946203,0.00001647149,0.000002481175,0.000007853661,0.0001801936,0.000008142633,0.0004977174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199988,"threshold_uncertainty_score":0.003802121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05477101688827125,"score_gpt":0.338922561517699,"score_spread":0.2841515446294278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}