{"id":"W4410628886","doi":"10.7554/elife.106720","title":"Progressive mural cell deficiencies across the lifespan in a foxf2 model of cerebral small vessel disease","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Disease; Mural; Medicine; Mural cell; Cardiology; Anatomy; Pathology; Internal medicine; History; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006873842,0.0008539687,0.0005964308,0.001221411,0.0006825979,0.0006357412,0.000855718,0.001511839,0.004801527],"category_scores_gemma":[0.0004401166,0.0004506344,0.0006358415,0.0003680524,0.0008744777,0.0005017964,0.0006103849,0.00240263,0.001165507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008528579,"about_ca_system_score_gemma":0.0008700204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003820304,"about_ca_topic_score_gemma":0.008019364,"domain_scores_codex":[0.9994722,0.00006002837,0.00006101079,0.0001294424,0.0001514666,0.0001259614],"domain_scores_gemma":[0.9991946,0.000103638,0.0001893416,0.00006238628,0.00006007938,0.0003899894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111231,0.0004923537,0.0007712545,0.0001643025,0.00005707355,0.001198179,0.0002957329,0.00102328,0.9848269,0.002764741,0.001920173,0.005374844],"study_design_scores_gemma":[0.0006703633,0.001774215,0.008788344,0.0001928878,0.0002069594,0.002795503,0.0005120694,0.01221019,0.9405537,0.001413198,0.03080881,0.00007377274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959511,0.001860843,0.02079151,0.001836446,0.0006552571,0.0002895762,0.005954827,0.001059285,0.008041347],"genre_scores_gemma":[0.9343041,0.001910789,0.01914883,0.0005042334,0.00008427582,0.0007725485,0.002793528,0.0005494462,0.03993212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004801527,"threshold_uncertainty_score":0.01606274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02522875526126812,"score_gpt":0.2928414292686624,"score_spread":0.2676126740073943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}