{"id":"W4410629097","doi":"10.21203/rs.3.rs-6716211/v1","title":"Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Depression (economics); Protocol (science); Antidepressant; Randomized controlled trial; Primary care; Resource (disambiguation); Medicine; Psychiatry; Antidepressant medication; Psychotherapist; Psychology; Alternative medicine; Anxiety; Family medicine; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03187263,0.006668173,0.009895087,0.002278869,0.003145283,0.004615257,0.002304994,0.007040435,0.06633954],"category_scores_gemma":[0.03910254,0.004041602,0.006815406,0.002709503,0.004250741,0.002559807,0.002312202,0.008485388,0.007887058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006075331,"about_ca_system_score_gemma":0.01235073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003621985,"about_ca_topic_score_gemma":0.005098751,"domain_scores_codex":[0.9719734,0.01722577,0.003395988,0.002431794,0.001958011,0.003014989],"domain_scores_gemma":[0.9847171,0.006407202,0.002894756,0.002245261,0.002248649,0.001487046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9284792,0.006675187,0.0006566711,0.01262529,0.003597703,0.0001384375,0.0003321238,0.003226552,0.001156522,0.005544868,0.01255616,0.02501126],"study_design_scores_gemma":[0.968844,0.009892971,0.0009909415,0.00143858,0.001281762,0.00003260054,0.00005294916,0.001796505,0.0004818238,0.002715924,0.01238666,0.00008516837],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.004224484,0.0003687592,0.00376246,0.0003190241,0.0004701633,0.9875228,0.001719768,0.0001729787,0.001439739],"genre_scores_gemma":[0.004817898,0.00012191,0.004468504,0.0001914225,0.00006528234,0.9896346,0.0001949459,0.00001340018,0.0004920697],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06633954,"threshold_uncertainty_score":0.2219279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09518256615933487,"score_gpt":0.4728084235932729,"score_spread":0.3776258574339381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}