{"id":"W4410629958","doi":"10.1152/physrev.00025.2024","title":"Deconstructing the GWAS library: next-generation GWAS","year":2025,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Ministry of Health -Singapore","keywords":"Genome-wide association study; Computational biology; Identification (biology); Disease; Genetic association; Genetic architecture; Mechanism (biology); Genetic variants; Biology; Bioinformatics; Single-nucleotide polymorphism; Medicine; Genetics; Phenotype; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006778074,0.0004801482,0.001748724,0.00004039411,0.0002580919,0.00005862659,0.0006765089,0.0006163844,0.0001363801],"category_scores_gemma":[0.001990201,0.0002511849,0.001024824,0.0002750225,0.000133159,0.000005735486,0.0004595564,0.0003831689,0.0001432869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001974449,"about_ca_system_score_gemma":0.0002191284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002882827,"about_ca_topic_score_gemma":0.000002893406,"domain_scores_codex":[0.9961016,0.001655522,0.001046858,0.0007278736,0.00007462246,0.0003935231],"domain_scores_gemma":[0.998156,0.0002374629,0.0007221386,0.0007736887,0.00003356974,0.00007715949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001364914,0.00002445239,0.00001680779,0.001388467,0.00008851958,4.266285e-7,0.000002600646,0.000005004931,0.0002190726,0.0002423059,0.1969839,0.801027],"study_design_scores_gemma":[0.00004572783,0.00006791036,0.00002803884,0.0009745106,0.0002424188,0.00000749843,0.000003900329,0.00001098602,0.000006629827,0.0001818287,0.9981614,0.0002691951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009190799,0.9971256,0.0001604358,0.0001403194,0.0003907109,0.001108391,0.00003482427,0.00002092263,0.0009268707],"genre_scores_gemma":[0.00006415521,0.9925323,0.001459627,0.001059664,0.001385057,0.0005204582,0.001416291,0.00002512867,0.001537342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8011774,"threshold_uncertainty_score":0.999994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1825099070823725,"score_gpt":0.3774976393222587,"score_spread":0.1949877322398862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}