{"id":"W4410631609","doi":"10.1371/journal.ppat.1013177","title":"Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Canada Research Chairs","keywords":"Transmission (telecommunications); Virology; Biology; Ex vivo; Sexual transmission; Immunology; Virus; Human immunodeficiency virus (HIV); Genetics; In vivo; Microbicide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801654,0.0002554203,0.0002052763,0.0001617317,0.0002109267,0.0002875362,0.0001237162,0.0002608385,0.001307138],"category_scores_gemma":[0.0002037955,0.0001210001,0.0002563029,0.0001262812,0.0001182673,0.0002106425,0.0002385249,0.0003779916,0.0001939208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001313219,"about_ca_system_score_gemma":0.0001500766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579495,"about_ca_topic_score_gemma":0.001474086,"domain_scores_codex":[0.9998167,0.00003574539,0.00001209168,0.00004684035,0.00004267401,0.00004603155],"domain_scores_gemma":[0.9998853,0.00003481633,0.00001858708,0.00001431927,0.00002092636,0.00002589994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001050991,0.00002756474,0.001508288,0.00002587969,0.00001057996,0.00004012214,0.00004179904,0.00004965733,0.9970078,0.00004368516,0.0000334129,0.001106194],"study_design_scores_gemma":[0.00003181516,0.002609382,0.08780669,0.00002481388,0.0000749137,0.00288812,0.0003044162,0.003223406,0.9010778,0.0001388622,0.001783509,0.00003643243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989638,0.0001952974,0.0004156997,0.000007077051,0.000002625068,0.00001101964,0.0001456436,0.000004381253,0.0002543432],"genre_scores_gemma":[0.9975758,0.000127829,0.0009239248,0.00002393323,0.000003127106,0.00001943899,0.000646294,0.000006294388,0.000673291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579495,"threshold_uncertainty_score":0.004372776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175478107391937,"score_gpt":0.2486302239048722,"score_spread":0.2310824131656785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}