{"id":"W4410633323","doi":"10.1016/j.neo.2025.101176","title":"PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents","year":2025,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"National Center for Advancing Translational Sciences; Clinical and Translational Science Center, Weill Cornell Medical College; Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Foundation for Innovation; National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center","keywords":"RNA splicing; Lung cancer; Cancer research; RNA; Alternative splicing; Molecular biology; DNA; Biology; Medicine; Gene; Messenger RNA; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122973,0.0003444343,0.0003422992,0.0002763755,0.0001346877,0.0002344562,0.0002237726,0.0002400974,0.001356067],"category_scores_gemma":[0.00008613591,0.0001223826,0.0002888223,0.0002150236,0.0001463877,0.0001413607,0.0001294222,0.0005247651,0.0002905977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035834,"about_ca_system_score_gemma":0.0002250296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005275993,"about_ca_topic_score_gemma":0.001642585,"domain_scores_codex":[0.9999112,0.00001714533,0.000008950839,0.00001481672,0.00002475109,0.00002310131],"domain_scores_gemma":[0.9999573,0.000007482576,0.00001161759,0.000005214198,0.000005770804,0.00001263834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439315,0.0001678562,0.0002151903,0.0000477967,0.00001588369,0.00003641859,0.00001134379,0.0002006883,0.9944243,0.00007111154,0.0001386308,0.004326826],"study_design_scores_gemma":[0.000108628,0.002102514,0.003565831,0.000006820448,0.00003313337,0.0001899601,0.00001967657,0.001322466,0.9897009,0.00003761065,0.002906955,0.00000549694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921162,0.00294983,0.001939451,0.0001429934,0.00004755369,0.00007017639,0.0003608069,0.0002481983,0.002124842],"genre_scores_gemma":[0.9959831,0.001153276,0.0008135153,0.00006395701,0.00001057781,0.00004361281,0.0003899974,0.00001874833,0.001523201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356067,"threshold_uncertainty_score":0.00453651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00583066562863572,"score_gpt":0.262289336034891,"score_spread":0.2564586704062553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}