{"id":"W4410698444","doi":"10.1016/j.ajt.2025.05.023","title":"Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection","year":2025,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Toronto Rehabilitation Institute; Toronto General Hospital; Stem Cell Network; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Novo Nordisk; Canada Foundation for Innovation; Canadian Society of Transplantation; Canada First Research Excellence Fund; Canada Research Chairs; Juvenile Diabetes Research Foundation Canada; Leona M. and Harry B. Helmsley Charitable Trust; Natural Sciences and Engineering Research Council of Canada; Diabetes Canada; Eli Lilly Canada; BC Children's Hospital; Eli Lilly and Company","keywords":"Medicine; Islet; Immunology; Function (biology); Cell therapy; Cell; Diabetes mellitus; Cell biology; Endocrinology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365361,0.0001309919,0.0002364473,0.0002371932,0.0001762715,0.00001966911,0.00006867546,0.00005576972,0.00003093335],"category_scores_gemma":[0.000005603585,0.0001006361,0.00004652847,0.0002314686,0.000200041,0.0002052861,0.000003341157,0.0002285204,0.000005179636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002380935,"about_ca_system_score_gemma":0.00006075961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001296298,"about_ca_topic_score_gemma":0.00007711759,"domain_scores_codex":[0.9991648,0.0001658602,0.0003040523,0.0001729434,0.00004359649,0.0001487006],"domain_scores_gemma":[0.9993916,0.00005884059,0.0003275908,0.00007749262,0.0001297936,0.00001471536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002104203,0.00008864899,0.002404296,0.00004625216,0.0001639549,0.00000477301,0.002756657,0.00002196196,0.9758194,0.00003927823,0.0002995141,0.01625104],"study_design_scores_gemma":[0.003209127,0.005471828,0.02725512,0.0003287571,0.0002195072,0.0002717275,0.001962062,0.000001177004,0.9542214,0.0001468986,0.006716033,0.0001963246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909515,0.0005942581,0.007175241,0.0001059309,0.0003202154,0.00009349805,0.00003052047,0.00001942935,0.0007094302],"genre_scores_gemma":[0.9978246,0.001288199,0.0001875669,0.0001694822,0.00004921544,0.000003674017,0.00004854813,0.000008695756,0.0004200216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02485083,"threshold_uncertainty_score":0.4103823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005375831572361725,"score_gpt":0.2195376307129176,"score_spread":0.2141617991405559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}