{"id":"W4410698444","doi":"10.1016/j.ajt.2025.05.023","title":"Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection","year":2025,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Toronto Rehabilitation Institute; Toronto General Hospital; Stem Cell Network; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Novo Nordisk; Canada Foundation for Innovation; Canadian Society of Transplantation; Canada First Research Excellence Fund; Canada Research Chairs; Juvenile Diabetes Research Foundation Canada; Leona M. and Harry B. Helmsley Charitable Trust; Natural Sciences and Engineering Research Council of Canada; Diabetes Canada; Eli Lilly Canada; BC Children's Hospital; Eli Lilly and Company","keywords":"Medicine; Islet; Immunology; Function (biology); Cell therapy; Cell; Diabetes mellitus; Cell biology; Endocrinology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607733,0.0005974601,0.0005302335,0.000332344,0.0002445285,0.0005252098,0.0002657294,0.00039455,0.001737261],"category_scores_gemma":[0.0001488538,0.0001297969,0.0002463439,0.0002398794,0.0004240539,0.0002391725,0.0001684433,0.001880384,0.0004654268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082465,"about_ca_system_score_gemma":0.0004056939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003465226,"about_ca_topic_score_gemma":0.0008293639,"domain_scores_codex":[0.9997959,0.00004141112,0.00001342595,0.00002277698,0.0000581428,0.00006838709],"domain_scores_gemma":[0.9998148,0.00004318898,0.00003201486,0.000022566,0.000009800729,0.00007766918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002223359,0.001098861,0.0004408617,0.00005649943,0.0000250121,0.0001130483,0.00004447915,0.0005182438,0.9887425,0.0003353421,0.0005073745,0.005894542],"study_design_scores_gemma":[0.0008645339,0.006980029,0.004798942,0.00002034228,0.00008138594,0.0003320484,0.00009072178,0.003290708,0.9775745,0.000177835,0.00577491,0.0000140678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957615,0.0008802614,0.001012547,0.0001617065,0.0001591793,0.00004027677,0.0001637575,0.0001021018,0.001718713],"genre_scores_gemma":[0.9956168,0.0005593551,0.0008966935,0.00009814999,0.00007980763,0.00007120577,0.0003859541,0.00001994068,0.002272116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737261,"threshold_uncertainty_score":0.005811751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005375831572361725,"score_gpt":0.2195376307129176,"score_spread":0.2141617991405559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}