{"id":"W4410701422","doi":"10.1111/jdv.20759","title":"Skin's molecular signature may help guide treatment of complex inflammatory skin diseases","year":2025,"lang":"en","type":"letter","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Sanofi; Eli Lilly and Company","keywords":"Medicine; Signature (topology); Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008863339,0.000368151,0.0006838197,0.0007568683,0.001138483,0.00156048,0.0005319691,0.007197286,0.009172491],"category_scores_gemma":[0.00762947,0.0001754634,0.0006942548,0.0002673844,0.001125164,0.002333273,0.0005645615,0.009999692,0.005360041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001148708,"about_ca_system_score_gemma":0.0009777457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542439,"about_ca_topic_score_gemma":0.002693913,"domain_scores_codex":[0.9994102,0.0002183724,0.00008185545,0.00006810647,0.0001284521,0.0000931516],"domain_scores_gemma":[0.9978193,0.001223685,0.00009057934,0.0001236196,0.0004436839,0.0002991489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.000244309,0.0002789274,0.01372904,0.0002004499,0.00004804782,0.04678717,0.0002624374,0.000646142,0.002309415,0.01410974,0.7861015,0.1352827],"study_design_scores_gemma":[0.0002196674,0.0003557046,0.01334514,0.001050033,0.00008450465,0.1151634,0.001081037,0.003267177,0.001433055,0.06061383,0.8032675,0.0001189414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.007073732,0.007733659,0.00164653,0.93113,0.01685463,0.00005219162,0.0001596224,0.0001433005,0.03520634],"genre_scores_gemma":[0.1498687,0.02014473,0.006303279,0.6529381,0.1240883,0.0001049642,0.0003501676,0.0001143209,0.0460875],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009172491,"threshold_uncertainty_score":0.03068507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428674917473066,"score_gpt":0.2809294782694476,"score_spread":0.2666427290947169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}