{"id":"W4410706661","doi":"10.1093/ced/llaf215","title":"Outcomes of Psoriasis Area and Severity Index (PASI) and PASI components in two phase III trials of deucravacitinib in patients with moderate to severe plaque psoriasis","year":2025,"lang":"en","type":"article","venue":"Clinical and Experimental Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Queen's University","funders":"Manchester Biomedical Research Centre; Bristol-Myers Squibb Canada; Samsung; LEO Pharma; Sun Pharma; Celgene; Teva Pharmaceutical Industries; National Institute for Health and Care Research; XBiotech; Celltrion; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Placebo; Medicine; Psoriasis Area and Severity Index; Plaque psoriasis; Erythema; Psoriasis; Desquamation; Internal medicine; Severity of illness; Clinical trial; Surgery; Gastroenterology; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003937017,0.0002867016,0.001783011,0.0002590398,0.00006620806,0.000007974684,0.000108914,0.0002999222,0.0000333783],"category_scores_gemma":[0.0001368132,0.000221711,0.00008911824,0.0001609133,0.0004488915,0.00008896895,0.0001823616,0.0001710973,0.000001639084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001709178,"about_ca_system_score_gemma":0.00004345018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003150942,"about_ca_topic_score_gemma":0.0001791764,"domain_scores_codex":[0.9970751,0.0007364058,0.001376192,0.0004786815,0.00004630255,0.0002873233],"domain_scores_gemma":[0.9985353,0.0008745338,0.0002858476,0.000195769,0.00004441957,0.00006410394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01542709,0.001929454,0.9722993,0.00003994478,0.0004573424,0.00001347032,0.0006381299,0.000002026145,0.00138896,0.000213494,0.00007362968,0.007517128],"study_design_scores_gemma":[0.07996192,0.000560332,0.8877878,0.0001262939,0.000133266,0.00002516096,0.0005601018,0.00002322814,0.03020136,0.0002526027,0.0001135629,0.0002543818],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974109,0.001078148,0.00002002805,0.0002111837,0.000321424,0.0006653599,0.0001685582,0.00001196718,0.0001124131],"genre_scores_gemma":[0.9992758,0.0001583288,0.0001361063,0.0002177989,0.000005172412,0.00006459392,0.0001008486,0.000009749005,0.00003162249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08451153,"threshold_uncertainty_score":0.9041112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650189664611037,"score_gpt":0.351055705697812,"score_spread":0.3045538090517016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}