{"id":"W4410708749","doi":"10.1159/000546477","title":"Circulating Cell-Free Tumor DNA-Based Liquid Biopsy of Cerebrospinal Fluid in Retinoblastoma","year":2025,"lang":"en","type":"article","venue":"Ocular Oncology and Pathology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Cerebrospinal fluid; Retinoblastoma; Liquid biopsy; Pathology; Biopsy; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004547267,0.0002331556,0.0003232885,0.0009790615,0.0002647114,0.0003845477,0.0002973761,0.0003384335,0.001086175],"category_scores_gemma":[0.0009563322,0.000109385,0.0001149505,0.0003144176,0.000311553,0.0003585634,0.0002368969,0.0002016074,0.0004539923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961182,"about_ca_system_score_gemma":0.0004223366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001746037,"about_ca_topic_score_gemma":0.001916491,"domain_scores_codex":[0.999792,0.0000509347,0.00002497914,0.00004819605,0.00005379926,0.00003002143],"domain_scores_gemma":[0.9997573,0.0000866234,0.00005068983,0.00001734316,0.00004444929,0.00004363652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005237995,0.000240678,0.6602773,0.0004159287,0.00007200846,0.03026668,0.0007976948,0.0005969008,0.214286,0.0002146215,0.000573873,0.08702041],"study_design_scores_gemma":[0.0003825518,0.004402651,0.6410844,0.0003025454,0.0002778438,0.1527101,0.001779702,0.009033503,0.1831398,0.0007589475,0.0060711,0.00005686624],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99589,0.001804334,0.001480228,0.00004207134,0.0000104641,0.00004076858,0.00009976446,0.0000297304,0.0006025619],"genre_scores_gemma":[0.9977108,0.0004376725,0.001523978,0.00003415699,0.000008171046,0.00001536297,0.000103646,0.000004647116,0.0001614727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001746037,"threshold_uncertainty_score":0.003633618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005442114741626849,"score_gpt":0.2477523071002457,"score_spread":0.2423101923586188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}