{"id":"W4410708749","doi":"10.1159/000546477","title":"Circulating Cell-Free Tumor DNA-Based Liquid Biopsy of Cerebrospinal Fluid in Retinoblastoma","year":2025,"lang":"en","type":"article","venue":"Ocular Oncology and Pathology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Cerebrospinal fluid; Retinoblastoma; Liquid biopsy; Pathology; Biopsy; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003518518,0.0001643949,0.0003282703,0.0001354735,0.00006374836,0.000005706378,0.0002083187,0.0003382138,0.00001557607],"category_scores_gemma":[0.0002790692,0.0001796637,0.00008317867,0.0001449369,0.0002805305,0.000002076154,0.0002188246,0.0001470331,0.000001792372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003346698,"about_ca_system_score_gemma":0.0003751847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002936478,"about_ca_topic_score_gemma":0.0001289877,"domain_scores_codex":[0.9987321,0.000159557,0.000360421,0.0004175235,0.00005106091,0.0002793232],"domain_scores_gemma":[0.9992325,0.0000831351,0.000136366,0.000423316,0.00007148512,0.00005316384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007787215,0.0002101007,0.02723981,0.0001106324,0.00002300753,0.0003755773,0.00005550523,0.0002806294,0.9683821,0.001104249,0.0004175165,0.001022162],"study_design_scores_gemma":[0.00755098,0.005475435,0.05714033,0.0001206789,0.0001236531,0.0005239247,0.0002285044,0.0006783519,0.8972543,0.001183036,0.0291267,0.0005940719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922908,0.001837482,0.001578642,0.0003883472,0.0002528297,0.000179843,0.00003464036,0.000006955627,0.003430453],"genre_scores_gemma":[0.9962966,0.0001337023,0.00230811,0.001037412,0.00006530713,0.00003261281,0.00005191973,0.00001386967,0.00006050408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07112775,"threshold_uncertainty_score":0.7326472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005442114741626849,"score_gpt":0.2477523071002457,"score_spread":0.2423101923586188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}