{"id":"W4410711764","doi":"10.1038/s41467-025-59979-6","title":"Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; NIHR Cambridge Biomedical Research Centre; Servicio Gallego de Salud; Instituto de Salud Carlos III; National Medical Research Council; Cancer Council Tasmania; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; U.S. Army; National Institutes of Health; National University Health System; Xunta de Galicia; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Centers for Disease Control and Prevention; Institut National Du Cancer; National Center for Chronic Disease Prevention and Health Promotion; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; University of Crete; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Russian Foundation for Basic Research; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; Huntsman Cancer Foundation; Robert Bosch Stiftung; Agency for Science, Technology and Research; Cancer Research UK; National University of Singapore; National Institute for Health and Care Research; National Research Foundation Singapore; National Research Foundation; National Breast Cancer Foundation; Engineering and Physical Sciences Research Council; European Commission; Research Promotion Foundation; King's College London; Government of Canada; University of Cambridge; Ministerio de Sanidad, Servicios Sociales e Igualdad; Scottish Funding Council; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Norges Forskningsråd; Scottish Government; Division of Cancer Prevention, National Cancer Institute; Breast Cancer Research Trust; Wellcome Trust; Fondation du cancer du sein du Québec; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Center for Agroforestry, University of Missouri; Genome Canada; Deutsches Krebsforschungszentrum; Ministerie van Volksgezondheid, Welzijn en Sport; University of California, San Francisco; U.S. Department of Health and Human Services; University of Wisconsin Carbone Cancer Center; Department of Health and Social Care; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; University of California; Cancer Council Victoria; Ministry of Science and Higher Education of the Russian Federation; California Department of Public Health; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council NSW; Susan G. 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