{"id":"W4410715612","doi":"10.3899/jrheum.2025-0390.o006","title":"DISTINCT MOLECULAR PROFILES OF REMISSION POST-CD19 CAR-T CELL THERAPY VERSUS STANDARD IMMUNOSUPPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immunosuppression; Lupus erythematosus; CD19; Immunology; Systemic disease; Immunopathology; Systemic therapy; Internal medicine; Peripheral blood; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152574,0.000130169,0.0002661823,0.0006208568,0.0001470534,0.0003390782,0.00007849528,0.0001794785,0.001289076],"category_scores_gemma":[0.0002397884,0.00007028254,0.0002222951,0.0003784356,0.0001165349,0.0001256208,0.0001516589,0.0002543826,0.0002049041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699954,"about_ca_system_score_gemma":0.0001112471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002183495,"about_ca_topic_score_gemma":0.0003188104,"domain_scores_codex":[0.9998654,0.00002306765,0.00001056618,0.00003431001,0.00003370147,0.00003289517],"domain_scores_gemma":[0.9998292,0.00004629354,0.000058357,0.000009405839,0.00001810076,0.0000386313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009406168,0.0002661543,0.1194062,0.000227715,0.0001797316,0.0003942488,0.000219312,0.0007088652,0.8274662,0.0002072058,0.0004207171,0.04109738],"study_design_scores_gemma":[0.0000749913,0.001344439,0.9420705,0.00001715374,0.0001407654,0.001081307,0.0002164918,0.001749023,0.05162921,0.0001959853,0.001464998,0.00001523105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981298,0.0006344328,0.0002528638,0.00002670994,0.000003226854,0.000007441201,0.0006637939,0.00001233315,0.0002693961],"genre_scores_gemma":[0.9969602,0.0003604308,0.0004464263,0.00004373485,0.000007728146,0.00002589954,0.001787219,0.000006217751,0.0003620703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289076,"threshold_uncertainty_score":0.004312396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310418662656219,"score_gpt":0.3020048341509757,"score_spread":0.2889006475244135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}