{"id":"W4410715617","doi":"10.3899/jrheum.2025-0390.pv013","title":"A NOVELLA OF MICE AND MEN: IMMUNOLOGICAL AND REPRODUCTIVE ALTERATIONS IN A PRISTANE-INDUCED MOUSE MODEL OF SYSTEMIC LUPUS ERYTHEMATOSUS AFTER HORMONAL THERAPY","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pristane; Hormone; Immunology; Hormonal therapy; Systemic disease; Lupus erythematosus; Connective tissue disease; Autoimmune disease; Systemic lupus erythematosus; Immunopathology; Autoimmunity; Internal medicine; Antibody; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000521694,0.0009972274,0.0006347531,0.001401498,0.0004461895,0.0006037402,0.0005099691,0.001012207,0.003240085],"category_scores_gemma":[0.0002013277,0.0004142825,0.0007316031,0.0004538989,0.0006274762,0.0006353559,0.0003799417,0.00166903,0.0009230209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003101308,"about_ca_system_score_gemma":0.0003918058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003767043,"about_ca_topic_score_gemma":0.0007383273,"domain_scores_codex":[0.9993217,0.000112958,0.00006922983,0.000218659,0.0001671701,0.0001103371],"domain_scores_gemma":[0.9996019,0.0000349804,0.0001069204,0.00006500736,0.00002494073,0.0001663236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001547848,0.001046403,0.0005063314,0.0001412394,0.00001879694,0.0003924704,0.00007792351,0.0001012958,0.9916945,0.0004173036,0.0002274987,0.003828357],"study_design_scores_gemma":[0.0006911932,0.02398083,0.01625863,0.0001168035,0.0001588747,0.004321179,0.0002507048,0.001647009,0.9270458,0.0005629472,0.02490348,0.00006265285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685716,0.00715267,0.01257579,0.0008205563,0.0004153934,0.0005381491,0.002941594,0.0006240585,0.006360176],"genre_scores_gemma":[0.9428713,0.005454225,0.01532268,0.0007375038,0.0001717491,0.001357306,0.003474244,0.0001696519,0.03044138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003240085,"threshold_uncertainty_score":0.01083916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007663990604395114,"score_gpt":0.2350547294003866,"score_spread":0.2273907387959915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}