{"id":"W4410715659","doi":"10.3899/jrheum.2025-0390.pv004","title":"GLOBAL IMMUNE REPERTOIRE PROFILING SUGGESTS MULTIFACETED UNRESOLVED DYSREGULATION UPON SYSTEMIC LUPUS ERYTHEMATOSUS IMMUNOSUPPRESSANT THERAPY","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immune dysregulation; Repertoire; Immunology; Immune system; Profiling (computer programming); Lupus erythematosus; Systemic lupus erythematosus; Antibody; Pathology; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266193,0.0001582116,0.0002475074,0.0003819966,0.0001724487,0.0004555121,0.0001072869,0.0002303613,0.002170814],"category_scores_gemma":[0.0003248243,0.00008166513,0.0001380441,0.000239049,0.0002200954,0.0001377677,0.000191562,0.0002736324,0.0002551433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001046411,"about_ca_system_score_gemma":0.00009161072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545351,"about_ca_topic_score_gemma":0.0003068109,"domain_scores_codex":[0.9997957,0.00004435639,0.00001835372,0.00006210702,0.00004266872,0.0000368054],"domain_scores_gemma":[0.999816,0.00005469413,0.00005402739,0.00002483593,0.00002238027,0.00002805405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004684563,0.0000434171,0.06186903,0.00008432451,0.00004267368,0.0002439946,0.0001684213,0.0001761986,0.9185881,0.0001232546,0.0002315825,0.0179605],"study_design_scores_gemma":[0.00002531303,0.001065481,0.8348138,0.00002853293,0.0001150614,0.002966636,0.0005225525,0.00139793,0.1547401,0.0004984401,0.003808649,0.00001754188],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966478,0.0007133749,0.001127289,0.00005184563,0.000009479793,0.000013226,0.000422977,0.00004171916,0.0009723916],"genre_scores_gemma":[0.9984951,0.0001431487,0.0006073559,0.00008100229,0.000009897513,0.00001179878,0.0002921024,0.000008458126,0.000351093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002170814,"threshold_uncertainty_score":0.007262051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695602716329645,"score_gpt":0.3009344733377345,"score_spread":0.2839784461744381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}