{"id":"W4410715660","doi":"10.3899/jrheum.2025-0390.pt019","title":"FERROPTOSIS AND PYROPTOSIS IN KIDNEY MACROPHAGES AND EPITHELIAL KIDNEY CELLS IS MEDIATED BY A METABOLIC SWITCH TOWARD GLYCOLYSIS IN LUPUS NEPHRITIS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Lupus nephritis; Pyroptosis; Kidney; Glycolysis; Systemic lupus erythematosus; Cancer research; Immunology; Cell biology; Pathology; Inflammasome; Internal medicine; Inflammation; Metabolism; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473879,0.0001506172,0.0001813534,0.000188528,0.0001464353,0.0001607106,0.0001030993,0.0002485052,0.001229988],"category_scores_gemma":[0.00004842902,0.0001108653,0.000195513,0.0001310153,0.0001773628,0.0001720419,0.0001679856,0.0002977512,0.000269593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691694,"about_ca_system_score_gemma":0.0001332644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002253293,"about_ca_topic_score_gemma":0.0003886083,"domain_scores_codex":[0.9998934,0.00002166041,0.000009789441,0.00002322325,0.0000206391,0.0000313413],"domain_scores_gemma":[0.9999636,0.000002784434,0.00001107787,0.000002439213,0.00000497468,0.00001505707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000789208,0.00004162051,0.001540354,0.00008131636,0.000004871631,0.000180606,0.00004222646,0.000023204,0.9958075,0.0001012567,0.00006003147,0.001327782],"study_design_scores_gemma":[0.0001797018,0.001691764,0.134613,0.00004173386,0.00004914361,0.003188943,0.0003630851,0.0009729837,0.8530346,0.0005322961,0.00531433,0.00001852524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993507,0.003261128,0.001341454,0.0001599949,0.0000304602,0.00002734513,0.0002020944,0.00003574159,0.00143476],"genre_scores_gemma":[0.994944,0.00147549,0.001005862,0.00005937201,0.00001268157,0.00003950298,0.000171883,0.000004399592,0.002286681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001229988,"threshold_uncertainty_score":0.004114747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003339794814804735,"score_gpt":0.2166947098988859,"score_spread":0.2133549150840812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}