{"id":"W4410715666","doi":"10.3899/jrheum.2025-0390.pt018","title":"SINGLE-CELL RNA SEQUENCING UNVEILS PROGRESSIVE IMMUNE DYSREGULATION FROM GENERAL POPULATION, PRECLINICAL SLE TO SLE PATIENTS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immune dysregulation; Immune system; Immunology; Population; RNA; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419921,0.000200418,0.0004164179,0.0005085616,0.0002994896,0.0007351608,0.0001375666,0.0003214178,0.003342168],"category_scores_gemma":[0.0005671002,0.0001537725,0.000362309,0.0004140307,0.0002289337,0.0001502224,0.0002683124,0.0004240717,0.000780854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765196,"about_ca_system_score_gemma":0.000169701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008828545,"about_ca_topic_score_gemma":0.001813845,"domain_scores_codex":[0.9997668,0.00003201076,0.00001690856,0.0001106041,0.00003726212,0.00003636203],"domain_scores_gemma":[0.9997792,0.0000748612,0.00004203476,0.00002336329,0.00004767548,0.00003289261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003178264,0.0001065898,0.3255965,0.000671092,0.0003702294,0.0009736902,0.001089586,0.001078463,0.6018568,0.0003753017,0.004072529,0.06063094],"study_design_scores_gemma":[0.00007945816,0.0006594236,0.9279906,0.0001251958,0.0003765518,0.002853469,0.001390425,0.003838489,0.04797893,0.001273521,0.01338325,0.00005070856],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817787,0.002410883,0.004093802,0.0002609586,0.00005046432,0.00003535569,0.009252994,0.0001471807,0.001969637],"genre_scores_gemma":[0.9880299,0.0008444254,0.002564137,0.0004278067,0.00004296054,0.00006841696,0.006453848,0.00005604275,0.001512468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003342168,"threshold_uncertainty_score":0.0111807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145785635569617,"score_gpt":0.2524713993029428,"score_spread":0.2410135429472466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}