{"id":"W4410715674","doi":"10.3899/jrheum.2025-0390.pv010","title":"ESTROGEN RECEPTOR ALPHA LOCALIZATION AFFECTS CYTOKINE GENE EXPRESSION AFTER TLR7 AGONISM IN LUPUS-PRONE MALES","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; TLR7; Estrogen receptor alpha; Agonism; Systemic lupus erythematosus; Alpha (finance); Estrogen; Estrogen receptor; Endocrinology; Internal medicine; Receptor; Gene expression; Cytokine; Gene; Toll-like receptor; Genetics; Biology; Innate immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816968,0.0002958917,0.0003519523,0.000663624,0.0001885348,0.0003696155,0.0001756955,0.00045621,0.005604543],"category_scores_gemma":[0.0001538013,0.0002474916,0.0004786234,0.0002123856,0.0003185943,0.0001996948,0.0002071635,0.0008861463,0.001483359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427415,"about_ca_system_score_gemma":0.0001429846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003792014,"about_ca_topic_score_gemma":0.0005525511,"domain_scores_codex":[0.9996608,0.00005678538,0.00002218059,0.0001000899,0.00005834896,0.0001017002],"domain_scores_gemma":[0.9996496,0.0000370385,0.0001125219,0.00002875725,0.00002109714,0.0001509174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00254937,0.0002749436,0.001133731,0.00004185504,0.0000112584,0.0002002874,0.00005362544,0.00003479017,0.9936816,0.00009466937,0.0001861263,0.00173778],"study_design_scores_gemma":[0.0003187458,0.008843515,0.07604061,0.00004517118,0.0001364511,0.001451735,0.0007089221,0.0006788118,0.9063065,0.0002325334,0.005197043,0.00003997894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945972,0.000779292,0.0008046012,0.0002056704,0.00008499705,0.00002734717,0.001951402,0.00006705295,0.001482251],"genre_scores_gemma":[0.9828576,0.0009423754,0.0008775857,0.0002313612,0.00005173213,0.0001494567,0.001843087,0.00006360593,0.01298314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005604543,"threshold_uncertainty_score":0.01874906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005447945923049804,"score_gpt":0.2267045727805758,"score_spread":0.221256626857526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}