{"id":"W4410715693","doi":"10.3899/jrheum.2025-0390.o060","title":"INVESTIGATING PREDICTIVE SERUM SOLUBLE MEDIATORS SPECIFIC TO ANA+ INDIVIDUALS AT RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH HIGH-THROUGHPUT PROTEOMICS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Proteomics; Immunology; Systemic disease; Lupus erythematosus; Connective tissue disease; Immunopathology; Autoimmune disease; Antibody; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004447677,0.0003168617,0.0003715772,0.0007925663,0.0003091266,0.0008166505,0.000164875,0.0003622287,0.001931261],"category_scores_gemma":[0.0005516062,0.0001310608,0.0003305801,0.000771359,0.0001497307,0.0002277502,0.0002953373,0.0003540505,0.0004608674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400752,"about_ca_system_score_gemma":0.0001318144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520657,"about_ca_topic_score_gemma":0.000813472,"domain_scores_codex":[0.9998258,0.00004028327,0.00001521254,0.00005517034,0.00002976779,0.00003373473],"domain_scores_gemma":[0.999736,0.00008120062,0.00008538229,0.00001559324,0.00003766885,0.00004418019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001026028,0.0001901006,0.9308162,0.0001242968,0.0001565826,0.0003304382,0.0001484958,0.0002155273,0.05139303,0.00009203122,0.0008053533,0.01470191],"study_design_scores_gemma":[0.00001308397,0.0003570586,0.9914292,0.00001561793,0.0001062993,0.0007094136,0.0002049867,0.000992146,0.005242734,0.0001516193,0.0007697479,0.000008088408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965731,0.0008021546,0.0008118729,0.0000981027,0.00001207798,0.0000252737,0.0008956557,0.00003812002,0.0007436422],"genre_scores_gemma":[0.9973858,0.0002742623,0.001215778,0.00007102249,0.0000203683,0.00002274696,0.0005871531,0.000007057413,0.00041577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001931261,"threshold_uncertainty_score":0.006460667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408525479520371,"score_gpt":0.2652768864411025,"score_spread":0.2511916316458988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}