{"id":"W4410715773","doi":"10.3899/jrheum.2025-0390.o035","title":"MULTIMODAL IMAGING APPROACH IN THE SUBCLINICAL DETECTION OF HYDROXYCHLOROQUINE-INDUCED RETINAL TOXICITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Hydroxychloroquine; Subclinical infection; Lupus erythematosus; Toxicity; Retinal; Retinopathy; Connective tissue disease; Systemic disease; Dermatology; Immunopathology; Internal medicine; Ophthalmology; Immunology; Autoimmune disease; Coronavirus disease 2019 (COVID-19); Diabetes mellitus; Endocrinology; Antibody; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002862711,0.0001876079,0.0008332261,0.0003943156,0.00005441123,0.000007933387,0.0003961678,0.0001424653,0.000001961232],"category_scores_gemma":[0.0006363678,0.00009981989,0.0001253865,0.0005502385,0.0001773832,0.00009538521,0.00006364907,0.001041266,0.000001372408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637727,"about_ca_system_score_gemma":0.0001900468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002108899,"about_ca_topic_score_gemma":0.0001133865,"domain_scores_codex":[0.996987,0.0009019517,0.001206118,0.000172117,0.0004358514,0.000296953],"domain_scores_gemma":[0.9979206,0.0006336811,0.0007616949,0.0004127662,0.0002209207,0.00005029624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002574736,0.0006729604,0.9902555,0.0002061192,0.00008131295,0.00002323571,0.001336555,0.0001123046,0.003557856,0.00007071095,0.000009008625,0.001099748],"study_design_scores_gemma":[0.01997892,0.001036639,0.9340121,0.002444412,0.0003232328,0.02569101,0.00476983,0.006321236,0.004915123,0.0002735472,0.000005498945,0.0002285082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970204,0.0001477212,0.001243032,0.0005428162,0.0002968916,0.0005311808,9.157068e-7,0.000008401986,0.0002086708],"genre_scores_gemma":[0.9996284,0.00002354463,0.0002195727,0.00009325368,0.000008368089,0.000006034836,0.000001233371,0.00001468413,0.000004859609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05624341,"threshold_uncertainty_score":0.4523842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057574341557813,"score_gpt":0.2629569859200542,"score_spread":0.252381242504476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}