{"id":"W4410715844","doi":"10.3899/jrheum.2025-0390.o002","title":"B-CELL ACTIVATING FACTOR INDUCES SYSTEMIC LUPUS ERYTHEMATOSUS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION VIA GZMK+ CD8+ T CELL-MEDIATED ENDOTHELIAL CELL APOPTOSIS","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitätsklinikum Erlangen; Faculty of Medicine and Health, University of Sydney; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Universidad de Granada; Pfizer; Karolinska Institutet; Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológic; Örebro Universitet; Friedrich-Alexander-Universität Erlangen-Nürnberg; National and Kapodistrian University of Athens","keywords":"Medicine; CD8; Apoptosis; Pulmonary hypertension; Immunology; Endothelial stem cell; Lupus erythematosus; Internal medicine; Immune system; Antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466061,0.00024271,0.0002363473,0.0002865627,0.0001323574,0.0002188703,0.0001175551,0.0003062326,0.004319595],"category_scores_gemma":[0.00009339933,0.0001323925,0.0002799584,0.0001664114,0.0001528931,0.0001176315,0.000172204,0.0007362356,0.000991528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142923,"about_ca_system_score_gemma":0.00009991221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001615569,"about_ca_topic_score_gemma":0.0003263595,"domain_scores_codex":[0.9997842,0.00004401309,0.00002091213,0.00003719978,0.00004043998,0.00007337618],"domain_scores_gemma":[0.9999263,0.000009988295,0.00002031802,0.00001013485,0.000005930508,0.00002727391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006254993,0.0001593992,0.0009590071,0.00007288822,0.0000165267,0.0001433835,0.00001895193,0.00006256676,0.9938327,0.00005818347,0.0004359769,0.003614851],"study_design_scores_gemma":[0.0006547347,0.005358632,0.1412521,0.00004413005,0.0001215234,0.002382823,0.0002635359,0.004018348,0.8352863,0.0004441252,0.01014728,0.00002662052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933961,0.001089799,0.001374505,0.0002262023,0.00007445529,0.00004728254,0.0008706478,0.0001728663,0.002748061],"genre_scores_gemma":[0.994011,0.000594925,0.0008455528,0.0002486752,0.00003493781,0.00007673154,0.0008531225,0.0000229818,0.003312024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319595,"threshold_uncertainty_score":0.01445055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698566329783955,"score_gpt":0.2502376939410192,"score_spread":0.2332520306431797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}