{"id":"W4410718389","doi":"10.1038/s41514-025-00228-x","title":"Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia","year":2025,"lang":"en","type":"article","venue":"npj Aging","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China; Chinese People’s Liberation Army; Natural Science Foundation of Shanghai","keywords":"Vascular dementia; Medicine; Dementia; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006312576,0.0005232422,0.0006531547,0.001329418,0.00053286,0.0007428851,0.0002708732,0.0004112194,0.001600271],"category_scores_gemma":[0.000587344,0.0001249697,0.0005894256,0.001047943,0.0002818817,0.0002639966,0.0004122205,0.0005193207,0.0001930342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005661238,"about_ca_system_score_gemma":0.0005005111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00307397,"about_ca_topic_score_gemma":0.003882104,"domain_scores_codex":[0.9997112,0.00004048137,0.00001925732,0.00009970887,0.0000697604,0.00005948963],"domain_scores_gemma":[0.9997544,0.0000555402,0.00008690546,0.00001918225,0.00005171818,0.00003226053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003351295,0.0002549738,0.4261032,0.002377481,0.001890648,0.001166296,0.0005196297,0.003541737,0.4550067,0.001765192,0.004903852,0.09911902],"study_design_scores_gemma":[0.00004940499,0.0003792955,0.9405799,0.0001803186,0.0009317301,0.001240766,0.0004030338,0.00663339,0.03868526,0.002141911,0.008715532,0.00005947071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670046,0.01675233,0.005425115,0.0005163368,0.00008087279,0.00006537428,0.007720735,0.0001614823,0.002273115],"genre_scores_gemma":[0.9864808,0.002947204,0.004593951,0.000270769,0.00002877005,0.00006728329,0.004514287,0.00001940853,0.001077485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00307397,"threshold_uncertainty_score":0.006112158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224213568710407,"score_gpt":0.2650020640045286,"score_spread":0.2527599283174245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}