{"id":"W4410729745","doi":"10.1101/2025.05.20.654286","title":"Dual Metabolic Blockade by Metformin and Dichloroacetate Induces Lethal Energy Crisis in Chemoresistant NSCLC","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Guelph","funders":"","keywords":"Metformin; Blockade; Dual (grammatical number); Medicine; Pharmacology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152158,0.0003074229,0.0004320467,0.0002123619,0.0001209626,0.0003024819,0.0001846998,0.0002418329,0.0006223334],"category_scores_gemma":[0.00009481005,0.0001282241,0.0002761955,0.0001617642,0.0001047471,0.0001434279,0.0001886346,0.0005110705,0.0002123882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440378,"about_ca_system_score_gemma":0.0002005457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006792766,"about_ca_topic_score_gemma":0.001157964,"domain_scores_codex":[0.9998659,0.00002837555,0.00001934505,0.00002041391,0.00003423247,0.00003178613],"domain_scores_gemma":[0.9999505,0.000009306524,0.000009191698,0.000007167464,0.000006628998,0.00001714991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000438918,0.0002122534,0.0006724563,0.00004411862,0.00002204647,0.00008607014,0.00001583168,0.0002311906,0.9945881,0.00006169779,0.00009783394,0.00352951],"study_design_scores_gemma":[0.000109297,0.003590955,0.00832883,0.000008612358,0.00005295671,0.0004976785,0.00005216175,0.002420153,0.9827098,0.00003214886,0.002190274,0.000007288082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976715,0.001008657,0.0004365426,0.00004805212,0.00002278336,0.00002717395,0.0001206676,0.00002516194,0.0006393649],"genre_scores_gemma":[0.9983211,0.0004634137,0.0004097349,0.00003242378,0.000006637094,0.00002480869,0.0002114824,0.000004914531,0.0005254406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006792766,"threshold_uncertainty_score":0.002081931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007262047641285224,"score_gpt":0.2141534335022504,"score_spread":0.2068913858609652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}