{"id":"W4410739704","doi":"10.1016/j.jhlto.2025.100299","title":"Ex vivo lung perfusion-to-lung transplant rat survival model with reproducible development of acute lung injury and graft rejection","year":2025,"lang":"en","type":"article","venue":"JHLT Open","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Hospital; University Health Network","funders":"Ontario Institute for Regenerative Medicine; Cystic Fibrosis Canada; International Society for Heart and Lung Transplantation; Cell Science Research Foundation; Kyoto University Foundation; United Therapeutics Corporation","keywords":"Lung; Medicine; Perfusion; Ex vivo; Lung transplantation; In vivo; Pathology; Cardiology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004746642,0.0009492203,0.0004077352,0.0005263313,0.0001911646,0.0002708131,0.0003932697,0.0004452704,0.001980722],"category_scores_gemma":[0.0001740811,0.0001994246,0.0005452837,0.0001890657,0.0005038009,0.0005206765,0.0004170277,0.001408108,0.0003285103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621648,"about_ca_system_score_gemma":0.0003288243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003430819,"about_ca_topic_score_gemma":0.000630051,"domain_scores_codex":[0.9996334,0.0000520316,0.00003927753,0.0000966742,0.00009208368,0.00008641012],"domain_scores_gemma":[0.9995407,0.00005024874,0.0001806619,0.00006560818,0.00005092792,0.0001119625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007004929,0.0004525007,0.001597125,0.00004812545,0.00001395424,0.0001693802,0.00003806477,0.0001348219,0.9952436,0.00008074167,0.0000315942,0.0014895],"study_design_scores_gemma":[0.0000381401,0.0110555,0.01582056,0.00001732136,0.00006475345,0.0009256624,0.0001062498,0.001269721,0.969908,0.00007139658,0.000708019,0.00001470543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946864,0.0003585124,0.004176548,0.00004288586,0.00002739556,0.00005702678,0.0001676633,0.00005013023,0.0004334438],"genre_scores_gemma":[0.9923453,0.0004387916,0.004120779,0.00006349615,0.00001581711,0.0001935496,0.0004783037,0.00002433818,0.002319691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980722,"threshold_uncertainty_score":0.006626189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392013118835649,"score_gpt":0.3531905789788788,"score_spread":0.3292704477905223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}