{"id":"W4410740982","doi":"10.1016/j.ijpharm.2025.125777","title":"A spray dried replicon vaccine platform for pandemic response","year":2025,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Health Economics; University of Alberta","funders":"Biomedical Advanced Research and Development Authority; U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response","keywords":"Replicon; Pandemic; Virology; Coronavirus disease 2019 (COVID-19); Spray drying; Chemistry; Medicine; Chromatography; Genome; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836117,0.0002959628,0.0002377837,0.0001406461,0.00015534,0.0003663955,0.0002620074,0.0004588866,0.003608119],"category_scores_gemma":[0.0002003297,0.0001815507,0.0002886241,0.00008239543,0.0001657917,0.0003805941,0.0002888804,0.0008102514,0.001560741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839276,"about_ca_system_score_gemma":0.0002384921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002837932,"about_ca_topic_score_gemma":0.0004083959,"domain_scores_codex":[0.9998788,0.0000201548,0.000005174482,0.00003057416,0.0000382942,0.00002709056],"domain_scores_gemma":[0.9999344,0.00001489695,0.00001288435,0.00001017662,0.00001173972,0.00001589291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023152,0.0000378215,0.0000826048,0.00005425809,0.00000998724,0.00005606521,0.00002060578,0.0003561529,0.9909724,0.0003234689,0.0006167518,0.007367522],"study_design_scores_gemma":[0.00004579737,0.001197462,0.0005219048,0.000008174023,0.00003376056,0.0001901153,0.00003102599,0.004160849,0.9803587,0.0001900117,0.01323891,0.0000232399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9067347,0.004972217,0.07202645,0.0009457456,0.001152824,0.0004523351,0.002119087,0.002412414,0.009184252],"genre_scores_gemma":[0.961773,0.001346895,0.02535714,0.0002879357,0.00007619271,0.0001607217,0.0009884101,0.0001107737,0.009898851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003608119,"threshold_uncertainty_score":0.0120703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05482091334762364,"score_gpt":0.4256183299478529,"score_spread":0.3707974166002292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}