{"id":"W4410741302","doi":"10.1038/s41531-025-01001-3","title":"T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease","year":2025,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Freedom Together Foundation; Aligning Science Across Parkinson’s; Vetenskapsrådet; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Substantia nigra; Hyposmia; Neuroinflammation; Disease; T cell; PINK1; Pathogenesis; Medicine; Alpha-synuclein; Immunology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990554,0.0002216595,0.0002294227,0.0004731342,0.0001814297,0.0002510276,0.00007853324,0.0002395445,0.001899145],"category_scores_gemma":[0.000323933,0.0001275165,0.00008529711,0.0001738215,0.0001714048,0.0001364221,0.0001628432,0.000245227,0.0002478269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000998762,"about_ca_system_score_gemma":0.00005956186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003228893,"about_ca_topic_score_gemma":0.0003615797,"domain_scores_codex":[0.9998921,0.00002547101,0.000008499607,0.00003130842,0.00002186765,0.00002083635],"domain_scores_gemma":[0.9998067,0.00002721437,0.00008399846,0.000008733746,0.0000207423,0.0000525672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004338858,0.0004203986,0.5298172,0.0002411217,0.00008262073,0.003049878,0.001159233,0.0001225449,0.4238152,0.0001475818,0.0005037552,0.03630171],"study_design_scores_gemma":[0.00002523332,0.0009646966,0.9843539,0.00001727521,0.00003396539,0.00354718,0.0002567357,0.0001153165,0.009611951,0.0001057065,0.0009622355,0.00000578556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998885,0.0005566916,0.00006956866,0.00001631867,0.000005034585,0.000003878367,0.00004149965,0.000004599074,0.0004175392],"genre_scores_gemma":[0.9992743,0.0001835077,0.0000520012,0.00002346785,0.000008978453,0.000004627921,0.00003912628,0.00000156376,0.0004124816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899145,"threshold_uncertainty_score":0.006353319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691616474888631,"score_gpt":0.2745923290759414,"score_spread":0.2576761643270551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}