{"id":"W4410743623","doi":"10.1111/1348-0421.13227","title":"Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in <i>Escherichia coli</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology and Immunology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Keio University","keywords":"Lytic cycle; Escherichia coli; Antibiotics; Microbiology; Vancomycin; Biology; Beta-lactam; Enterobacteriaceae; Bacteria; Genetics; Staphylococcus aureus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005352537,0.0003838922,0.0005821671,0.0002084865,0.000161761,0.00002782297,0.000481286,0.0005850871,0.00004123676],"category_scores_gemma":[0.0005114419,0.0003800483,0.00009886337,0.0004301531,0.0006539155,0.00001006843,0.0003556844,0.0002857353,0.0000304217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008490003,"about_ca_system_score_gemma":0.0002569785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002914619,"about_ca_topic_score_gemma":0.002801118,"domain_scores_codex":[0.9970658,0.0004278493,0.0006343584,0.001107372,0.00003602093,0.0007286346],"domain_scores_gemma":[0.9988341,0.0001053637,0.00009185421,0.0007385919,0.0001201375,0.0001099319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001166172,0.0003455621,0.07750037,0.00005445099,0.00005292565,0.000006862359,0.00009496325,0.00001038114,0.9193785,0.0001159306,0.0007240944,0.0005497644],"study_design_scores_gemma":[0.001022727,0.0009628339,0.2223096,0.00007136043,0.00003267106,0.00002818248,0.0003562335,0.000002338106,0.7687232,0.000116367,0.005951326,0.0004232097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955107,0.001428844,0.0006820931,0.0006883868,0.0004494917,0.0007316077,0.0001310897,0.00003056327,0.0003472397],"genre_scores_gemma":[0.9959874,0.0002758994,0.001500465,0.001494275,0.00004015849,0.000006974188,0.0001309903,0.00002082924,0.0005430187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1506553,"threshold_uncertainty_score":0.9998651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005818123942338357,"score_gpt":0.240821777841378,"score_spread":0.2350036538990397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}