{"id":"W4410743623","doi":"10.1111/1348-0421.13227","title":"Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in <i>Escherichia coli</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology and Immunology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Keio University","keywords":"Lytic cycle; Escherichia coli; Antibiotics; Microbiology; Vancomycin; Biology; Beta-lactam; Enterobacteriaceae; Bacteria; Genetics; Staphylococcus aureus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009089657,0.0004201364,0.0003570593,0.0003070933,0.00009088374,0.0004141712,0.0002227999,0.0003260436,0.00104671],"category_scores_gemma":[0.0001662435,0.0002353004,0.0003014472,0.000169144,0.0002988429,0.0001476632,0.0002850596,0.0004325874,0.0002613321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683866,"about_ca_system_score_gemma":0.0001860573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009899272,"about_ca_topic_score_gemma":0.001282848,"domain_scores_codex":[0.9997795,0.00003363327,0.00003559924,0.0000505889,0.00005936911,0.00004127277],"domain_scores_gemma":[0.9997597,0.0000344445,0.0000833067,0.00001997838,0.00001776968,0.00008474045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005529857,0.00001979386,0.000229206,0.00001161965,0.000003675185,0.00004023878,0.000005732213,0.00001614756,0.9992341,0.00001784512,0.00001061956,0.0003557792],"study_design_scores_gemma":[0.00001191878,0.0002213782,0.01371556,0.000008001735,0.00002256267,0.0003984736,0.00004903471,0.0004953431,0.9842291,0.00002265482,0.0008189972,0.000007036466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980047,0.0003947181,0.0008760127,0.00005199252,0.00001292454,0.000009288449,0.0002095512,0.00004598714,0.0003947536],"genre_scores_gemma":[0.9960244,0.0004215488,0.00132246,0.0000646519,0.000005029319,0.0000156843,0.0003642308,0.00004043645,0.001741698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104671,"threshold_uncertainty_score":0.003501594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005818123942338357,"score_gpt":0.240821777841378,"score_spread":0.2350036538990397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}