{"id":"W4410748172","doi":"10.1002/cbic.202500220","title":"Chemical Switching: A Concept Inspired by Strategies from Biocatalysis and Organocatalysis","year":2025,"lang":"en","type":"review","venue":"ChemBioChem","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innovative Medicines Initiative; European Federation of Pharmaceutical Industries and Associations; Ontario Institute for Cancer Research; McGill University; Diamond Light Source; Kungliga Tekniska Högskolan","keywords":"Biocatalysis; Organocatalysis; Function (biology); Protein function; Synthetic biology; DNA; Biochemical engineering; Reactive intermediate; Chemistry; Nanotechnology; Computational biology; Biology; Biochemistry; Reaction mechanism; Enantioselective synthesis; Materials science; Catalysis; Genetics; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007096413,0.001051711,0.000848455,0.001956033,0.0003978674,0.001328158,0.0009603812,0.001488745,0.002538635],"category_scores_gemma":[0.0005580984,0.000386725,0.0004947275,0.001769526,0.001511561,0.002642639,0.000968403,0.003689405,0.001717846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001304735,"about_ca_system_score_gemma":0.0009341946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007230086,"about_ca_topic_score_gemma":0.001108249,"domain_scores_codex":[0.9997275,0.00005061205,0.00002234347,0.00006494155,0.00009958972,0.00003502379],"domain_scores_gemma":[0.9997852,0.0001265716,0.00002351535,0.00001044505,0.0000339406,0.00002026137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009922859,0.0001357303,0.0001306003,0.01907946,0.0001000223,0.0005001917,0.0002789939,0.001442529,0.01691159,0.1293855,0.0306052,0.8013309],"study_design_scores_gemma":[0.000008135707,0.00008358006,0.0001055601,0.0007468536,0.00002225907,0.0006225725,0.00004322398,0.0001507773,0.002771251,0.007816561,0.9876091,0.00002001381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003040259,0.9910025,0.002327298,0.0005555895,0.0007312885,0.00001271605,0.00001531022,0.0000283649,0.005022903],"genre_scores_gemma":[0.004100267,0.9901437,0.001484121,0.0008250358,0.0004448434,0.00002844546,0.00003547705,0.0000104941,0.002927653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002538635,"threshold_uncertainty_score":0.009466529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112416388770994,"score_gpt":0.2682300028366537,"score_spread":0.2591175864478827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}