{"id":"W4410754945","doi":"10.1038/s43018-025-00964-9","title":"Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions","year":2025,"lang":"en","type":"article","venue":"Nature Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Neurological Disorders and Stroke","keywords":"microRNA; Cell biology; Biology; Receptor; Ligand (biochemistry); Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003517315,0.0001361231,0.0001437332,0.00005561511,0.00005754154,0.00001476533,0.0000927638,0.000163063,0.00003160182],"category_scores_gemma":[0.00003185456,0.0001185011,0.00004984311,0.0001138277,0.0001119725,0.000005509764,0.00005076939,0.000186442,4.624347e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003904211,"about_ca_system_score_gemma":0.0001358543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002018051,"about_ca_topic_score_gemma":0.00009024842,"domain_scores_codex":[0.9993435,0.00002785396,0.0001416462,0.0002803461,0.00008175846,0.0001249656],"domain_scores_gemma":[0.9995281,0.00001613569,0.0001181691,0.0001683643,0.0001245953,0.00004461369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002556669,0.0000293444,0.005613077,0.00005853878,0.000139,7.29245e-7,0.0000238145,0.00003560948,0.9813202,0.00001132634,0.01194419,0.0005684958],"study_design_scores_gemma":[0.0005829205,0.00003954586,0.008264147,0.0001267018,0.00004656248,0.000001810877,0.00004813896,0.0000682442,0.9529526,0.00001323678,0.03772718,0.0001288864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786355,0.02018223,0.0001462528,0.0003663814,0.0001329075,0.0001690275,0.0002960037,0.000008372981,0.00006331763],"genre_scores_gemma":[0.9978095,0.000180554,0.000332366,0.0002640589,0.00008597923,0.00002837485,0.0002230054,0.00001518212,0.001061038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02836758,"threshold_uncertainty_score":0.4832334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003402265089879285,"score_gpt":0.250958903548317,"score_spread":0.2475566384584377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}