{"id":"W4410754945","doi":"10.1038/s43018-025-00964-9","title":"Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions","year":2025,"lang":"en","type":"article","venue":"Nature Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Neurological Disorders and Stroke","keywords":"microRNA; Cell biology; Biology; Receptor; Ligand (biochemistry); Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044432,0.0001585818,0.0001443975,0.0004443835,0.0001834911,0.0004391393,0.0000919561,0.0001624578,0.000446797],"category_scores_gemma":[0.0001416875,0.0002325482,0.0001802494,0.0002257792,0.0002483198,0.000218745,0.0002447508,0.0002483103,0.0001316111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072502,"about_ca_system_score_gemma":0.0001666887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008252492,"about_ca_topic_score_gemma":0.001804747,"domain_scores_codex":[0.9998884,0.00001336595,0.000007327715,0.00003342754,0.00003417238,0.00002335239],"domain_scores_gemma":[0.9998947,0.0000184482,0.0000444568,0.00001087051,0.00001604367,0.00001540926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006339335,0.000004510573,0.008149603,0.00002139857,0.00001520822,0.0001964448,0.0000859656,0.0001782039,0.9890827,0.0002536907,0.00003897554,0.001909915],"study_design_scores_gemma":[0.000009567877,0.0001186738,0.2751239,0.00001196123,0.00005967384,0.002662328,0.0004212593,0.004557899,0.7109895,0.0005085975,0.005505112,0.00003157835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936057,0.0006419753,0.004751744,0.00002576193,0.000003475009,0.00001333888,0.0002266852,0.00005778612,0.0006735419],"genre_scores_gemma":[0.9933148,0.0003014595,0.005440427,0.00002636232,0.000001959353,0.00001744275,0.0002832992,0.000016926,0.0005972732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008252492,"threshold_uncertainty_score":0.001640856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003402265089879285,"score_gpt":0.250958903548317,"score_spread":0.2475566384584377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}