{"id":"W4410761172","doi":"10.1016/j.jcjo.2025.05.005","title":"Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Ophthalmology","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Société Canadienne de Pédiatrie","keywords":"Adverse Event Reporting System; Medicine; Pharmacovigilance; Optic nerve hypoplasia; Adverse effect; Odds ratio; Internal medicine; Database; Dysplasia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660693,0.0003523251,0.001005669,0.003206152,0.0005323612,0.001140528,0.0007020904,0.0008067318,0.004598462],"category_scores_gemma":[0.01193375,0.0002554598,0.001326937,0.005072396,0.0001981156,0.000591754,0.000679162,0.0007719995,0.0008908152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001271919,"about_ca_system_score_gemma":0.002385102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02195654,"about_ca_topic_score_gemma":0.03403853,"domain_scores_codex":[0.9966948,0.000367879,0.001269417,0.0005459741,0.0009470345,0.0001748465],"domain_scores_gemma":[0.980352,0.004130764,0.01127548,0.0009713529,0.002615495,0.0006550321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0031342,0.0001928013,0.9079247,0.00318255,0.001929802,0.001261118,0.0001491333,0.0005277074,0.001250028,0.0006059489,0.04235993,0.03748205],"study_design_scores_gemma":[0.0004608328,0.0002391266,0.9545569,0.0008304382,0.001796543,0.002249224,0.0001503898,0.0005381693,0.001097086,0.000219388,0.03780758,0.00005417572],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.4499558,0.01907016,0.0009589259,0.001007389,0.0001199303,0.0008605476,0.5129109,0.0001557982,0.0149605],"genre_scores_gemma":[0.68779,0.01024279,0.002391497,0.001789865,0.0002019076,0.000871742,0.2937579,0.00006511082,0.00288911],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02195654,"threshold_uncertainty_score":0.04365748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02993100371555033,"score_gpt":0.298738426067634,"score_spread":0.2688074223520837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}