{"id":"W4410764613","doi":"10.1093/brain/awaf195","title":"Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Ontario Brain Institute; Sunnybrook Health Science Centre; Montreal Neurological Institute and Hospital; University of Toronto; Western University; Occupational Cancer Research Centre; Université Laval","funders":"National Institute of Mental Health; NIHR Cambridge Biomedical Research Centre; Engineering and Physical Sciences Research Council; Medical Research Council; National Institute of Child Health and Human Development; University of California, San Diego; University of California, Los Angeles; National Institutes of Health; Medical Research Council Canada; Université de Bordeaux; Agence Nationale de la Recherche; National Institute for Health and Care Research; Northern California Institute for Research and Education; Ministerio de Ciencia e Innovación; Department of Health and Social Care; Canadian Institutes of Health Research","keywords":"C9orf72; Frontotemporal lobar degeneration; Atrophy; Frontotemporal dementia; Mutation; Asymptomatic carrier; Thalamus; Pathology; Neuroscience; Psychology; Medicine; Asymptomatic; Biology; Genetics; Dementia; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002916574,0.00006055944,0.0001232825,0.00003939838,0.00007448562,0.00001593433,0.000090899,0.00007459408,0.00004358205],"category_scores_gemma":[0.000170387,0.00003604677,0.00005061707,0.0001929641,0.0001019554,0.00002427719,0.00006140715,0.0001180793,0.00001698492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003029965,"about_ca_system_score_gemma":0.000137694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006886766,"about_ca_topic_score_gemma":0.00008571409,"domain_scores_codex":[0.9992479,0.0000727576,0.0001719423,0.0001318345,0.0002106351,0.0001649021],"domain_scores_gemma":[0.9995771,0.00005425128,0.00002837905,0.0002276491,0.00006799091,0.00004464218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006313196,0.0003914539,0.4366318,0.0002368592,0.0001222272,0.00004837093,0.0009707041,0.00001536197,0.1760188,0.0009742078,0.09529533,0.2886635],"study_design_scores_gemma":[0.001913096,0.0003991525,0.8993246,0.0001812591,0.00003014807,0.0000143887,0.0003038162,0.006125928,0.05759996,0.0002141861,0.03380262,0.00009087414],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989683,0.000801729,0.0003744707,0.007845185,0.00006247246,0.0003359596,0.000004925445,0.00001604919,0.0008761541],"genre_scores_gemma":[0.9955781,0.00001676388,0.0006081109,0.000482432,0.00008679216,0.00001431472,0.00001527907,0.000005957569,0.003192302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4626928,"threshold_uncertainty_score":0.1469945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807851780809519,"score_gpt":0.3817723781521348,"score_spread":0.3636938603440396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}