{"id":"W4410769627","doi":"10.1161/circulationaha.124.072636","title":"Blood Pressure Lowering Effects of a Novel Long-Acting NPR1 Agonist, XXB750, in Healthy Participants: A Randomized, First-in-Human Clinical Study","year":2025,"lang":"en","type":"letter","venue":"Circulation","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Medicine; Agonist; Blood pressure; Randomized controlled trial; Internal medicine; Pharmacology; Cardiology; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021233,0.0007114788,0.002097027,0.0001748365,0.0005837537,0.0009301127,0.0007464272,0.005434327,0.003239176],"category_scores_gemma":[0.004504893,0.0003488794,0.001013726,0.0002668384,0.0006639425,0.0005173272,0.0001974644,0.003297084,0.000855574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008937232,"about_ca_system_score_gemma":0.0008611878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381939,"about_ca_topic_score_gemma":0.002912717,"domain_scores_codex":[0.9989333,0.0006242772,0.00009923936,0.0001248925,0.0001311116,0.00008724839],"domain_scores_gemma":[0.9973137,0.001698547,0.0002925871,0.00009702802,0.0002118897,0.0003862839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6825338,0.006600644,0.01646626,0.002108501,0.00384271,0.004423759,0.0002755302,0.0003428581,0.01365426,0.0008224637,0.1295194,0.1394099],"study_design_scores_gemma":[0.7327174,0.08965834,0.08463606,0.0007421661,0.007533152,0.003230475,0.0004338298,0.002644667,0.004995683,0.003007686,0.07021241,0.0001881645],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7618828,0.03202603,0.001575249,0.1615447,0.02391054,0.001577456,0.003916834,0.0002432191,0.01332316],"genre_scores_gemma":[0.7855681,0.008338422,0.002437176,0.1706066,0.02127935,0.001372757,0.001057376,0.00004247309,0.009297799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005434327,"threshold_uncertainty_score":0.01122922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04168298535645832,"score_gpt":0.3450346019046535,"score_spread":0.3033516165481952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}