{"id":"W4410769837","doi":"10.1371/journal.ppat.1013220","title":"Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Echinocandin; Caspofungin; Echinocandins; Candida tropicalis; Biology; Multidrug tolerance; Microbiology; Antifungal; Bacteria; Biofilm; Fluconazole; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003191918,0.0002168603,0.0007892323,0.0001120257,0.00006672002,0.00001623336,0.000147126,0.000229211,0.0001062156],"category_scores_gemma":[0.0009418972,0.0001664653,0.0001662429,0.0002943316,0.0001192086,0.00002920689,0.0000870951,0.0004513542,0.00003996714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416173,"about_ca_system_score_gemma":0.0001465483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629888,"about_ca_topic_score_gemma":0.001630557,"domain_scores_codex":[0.9980835,0.0001511957,0.0005025822,0.0005925225,0.0002519247,0.0004182408],"domain_scores_gemma":[0.9989393,0.0003091052,0.0000579178,0.0003727864,0.00008852102,0.0002323317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006675984,0.0003698144,0.9800823,0.00003846038,0.00006357532,0.0002460505,0.000124104,0.000002097995,0.01134789,0.000243841,0.00161099,0.005203288],"study_design_scores_gemma":[0.001507455,0.0004974639,0.9921594,0.0002370596,0.00007926256,0.000002081395,0.000210334,0.0003399499,0.002245793,0.0001239982,0.00240698,0.0001902657],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838062,0.0003230895,0.0007146158,0.01233921,0.0001590984,0.0006635152,0.0001495946,0.00007074156,0.001773926],"genre_scores_gemma":[0.9887701,0.0001454524,0.001181066,0.008165988,0.00009278936,0.00006151871,0.00002300846,0.00001390211,0.001546121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01207706,"threshold_uncertainty_score":0.6788259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05292464684371894,"score_gpt":0.3452475391385247,"score_spread":0.2923228922948058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}