{"id":"W4410769837","doi":"10.1371/journal.ppat.1013220","title":"Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Echinocandin; Caspofungin; Echinocandins; Candida tropicalis; Biology; Multidrug tolerance; Microbiology; Antifungal; Bacteria; Biofilm; Fluconazole; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002391985,0.0003234294,0.000276386,0.0008398232,0.0003247951,0.0006501842,0.0001668035,0.0002676989,0.0008859598],"category_scores_gemma":[0.0005581439,0.0001111341,0.0002622843,0.0006870624,0.0002807043,0.0002217464,0.0003352465,0.0003878801,0.0001067553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515703,"about_ca_system_score_gemma":0.0002083049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513934,"about_ca_topic_score_gemma":0.001709589,"domain_scores_codex":[0.9997475,0.0000327465,0.00003123364,0.0000561061,0.00005683159,0.00007557709],"domain_scores_gemma":[0.999411,0.00004837658,0.0003492311,0.00004203363,0.00007772233,0.0000717205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001633584,0.0001574973,0.547958,0.0003514425,0.0001992611,0.002768698,0.0003814329,0.0005002449,0.4194892,0.0002215098,0.0005388377,0.02580031],"study_design_scores_gemma":[0.000008181903,0.0001776977,0.9680842,0.00003080503,0.00009360932,0.002531552,0.0004018299,0.0006597973,0.02653637,0.000135095,0.001322463,0.00001851715],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975142,0.0009766902,0.0004889045,0.00006221032,0.000008698899,0.00002468955,0.000462716,0.00001825874,0.0004435345],"genre_scores_gemma":[0.998367,0.0004636956,0.0004369929,0.00003909907,0.000008438864,0.00001328144,0.0004811951,0.000004959694,0.0001852689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513934,"threshold_uncertainty_score":0.003010273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05292464684371894,"score_gpt":0.3452475391385247,"score_spread":0.2923228922948058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}