{"id":"W4410770658","doi":"10.1080/14796694.2025.2511587","title":"Advances in IDH-mutant glioma management: IDH inhibitors, clinical implications of INDIGO trial, and future perspectives","year":2025,"lang":"en","type":"review","venue":"Future Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Glioma; Mutant; Clinical trial; Oncology; Indigo; Internal medicine; Cancer research; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003986835,0.0004531421,0.003090835,0.0007913915,0.00007362851,0.00001244413,0.0001942886,0.0009694682,0.00004295278],"category_scores_gemma":[0.00008009761,0.000321165,0.0005702945,0.0009798373,0.000198646,0.00006422229,0.0001832315,0.000631979,0.000007028416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003654333,"about_ca_system_score_gemma":0.0006198822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005127522,"about_ca_topic_score_gemma":0.00008319573,"domain_scores_codex":[0.9969704,0.0004003272,0.001336117,0.0007924953,0.0001724148,0.0003282404],"domain_scores_gemma":[0.9979056,0.0005938787,0.0006987363,0.000557153,0.0001009902,0.0001436862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000715774,0.001982066,0.0002931771,0.008055597,0.0005111152,0.0002678118,0.0001191313,1.7618e-8,4.060202e-7,0.01918681,0.00211019,0.9667579],"study_design_scores_gemma":[0.01661758,0.001393206,0.0007892703,0.004756389,0.002570743,0.0001134755,0.001247924,4.034023e-8,0.000001101689,0.0002662316,0.9720424,0.0002016725],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002975997,0.9837205,0.000001144084,0.003645437,0.001503765,0.003665459,0.0001140252,0.00003160783,0.007020404],"genre_scores_gemma":[0.0002347211,0.9951109,0.0004077874,0.00008647973,0.002931156,0.001004013,0.0001616916,0.00003082855,0.0000323924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9699322,"threshold_uncertainty_score":0.9999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893930662378556,"score_gpt":0.4262713615564876,"score_spread":0.397332054932702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}