{"id":"W4410770658","doi":"10.1080/14796694.2025.2511587","title":"Advances in IDH-mutant glioma management: IDH inhibitors, clinical implications of INDIGO trial, and future perspectives","year":2025,"lang":"en","type":"review","venue":"Future Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Glioma; Mutant; Clinical trial; Oncology; Indigo; Internal medicine; Cancer research; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001435387,0.0006025301,0.0014435,0.00149756,0.0002096073,0.00118339,0.001014681,0.00123815,0.003144604],"category_scores_gemma":[0.001488223,0.0002461977,0.0007176248,0.001560364,0.0004639593,0.001540158,0.0005740342,0.002477469,0.00132684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000901135,"about_ca_system_score_gemma":0.001542676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008493055,"about_ca_topic_score_gemma":0.002806641,"domain_scores_codex":[0.9997441,0.00007049563,0.00003746966,0.00004032753,0.00007796497,0.00002972854],"domain_scores_gemma":[0.9994088,0.0002991972,0.00007481086,0.00001317225,0.0001527818,0.00005128506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002438874,0.00007770484,0.0001362036,0.01460251,0.000116867,0.000167649,0.00005250948,0.0004341623,0.0007879104,0.004548754,0.03659864,0.9422332],"study_design_scores_gemma":[0.0001101708,0.0002324821,0.0007184325,0.008112011,0.0002244963,0.0009774474,0.00006495379,0.0002257561,0.0003318477,0.003677408,0.9853004,0.00002450315],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009085779,0.9985689,0.00005458633,0.000644983,0.0001869287,0.000003095468,0.00001189789,0.000004512504,0.000434198],"genre_scores_gemma":[0.000650562,0.9979772,0.0001338802,0.0006468618,0.000226472,0.000007169369,0.00002591854,0.00000190129,0.0003301127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003144604,"threshold_uncertainty_score":0.01051968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893930662378556,"score_gpt":0.4262713615564876,"score_spread":0.397332054932702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}