{"id":"W4410773123","doi":"10.1016/j.jtho.2025.05.017","title":"Successful Pregnancy and Healthy Baby Outcome in a Patient With Tyrosine Kinase Inhibitor–Refractory ALK-Positive NSCLC and Central Nervous System Metastasis Treated With Lorlatinib With Maternal-Fetal Pharmacokinetics and Child Milestone Development Correlations","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"West China Hospital, Sichuan University; Sichuan University","keywords":"Medicine; Milestone; Refractory (planetary science); Pregnancy; Fetus; Pharmacokinetics; Obstetrics; Pediatrics; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909653,0.0003257102,0.0004273757,0.0004315587,0.0006478041,0.0003900305,0.0003960944,0.001236912,0.0008802057],"category_scores_gemma":[0.00158359,0.0002038823,0.000461576,0.0002102925,0.0004756588,0.0003732876,0.0004457811,0.001458372,0.0001846526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007879328,"about_ca_system_score_gemma":0.0006376745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002602784,"about_ca_topic_score_gemma":0.002118651,"domain_scores_codex":[0.9998007,0.00003871178,0.0000170593,0.00004410054,0.00002642834,0.00007300306],"domain_scores_gemma":[0.9995173,0.0001855797,0.00007085299,0.00002655412,0.00002187943,0.0001776813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0009197936,0.0002272998,0.09456892,0.00003274657,0.00004548319,0.8863425,0.0002686091,0.0006224783,0.002902716,0.000540579,0.0006860684,0.01284285],"study_design_scores_gemma":[0.00006223084,0.001770701,0.08618735,0.00005207079,0.00009340057,0.9047587,0.0005217289,0.001926022,0.002062298,0.001009109,0.001500865,0.00005547307],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872936,0.002205671,0.001197933,0.004210986,0.0002030088,0.00004332616,0.0002775765,0.0000419845,0.004526],"genre_scores_gemma":[0.9974455,0.0009028836,0.0004536004,0.0003805457,0.00008160188,0.000009833519,0.000158327,0.000008158277,0.0005596703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602784,"threshold_uncertainty_score":0.00571686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045424596358966,"score_gpt":0.3527189224648989,"score_spread":0.3422646765013092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}