{"id":"W4410773377","doi":"10.1172/jci.insight.176676","title":"A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); McGill University Health Centre; McGill University","funders":"CSL Behring; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Merck Canada; Janssen Pharmaceuticals; Cidara Therapeutics","keywords":"Immunology; Medicine; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004925255,0.0002828624,0.0005590554,0.0005231941,0.0002786354,0.00005869761,0.0001853838,0.000197382,0.00004085519],"category_scores_gemma":[0.0002806043,0.0002602041,0.000236871,0.0006976614,0.0001339154,0.0002049676,0.0001076531,0.0003460301,0.00003494841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001598623,"about_ca_system_score_gemma":0.001051895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036683,"about_ca_topic_score_gemma":0.002706566,"domain_scores_codex":[0.9977973,0.0001763839,0.0005400266,0.0006347326,0.0002871942,0.0005643883],"domain_scores_gemma":[0.9987521,0.0001724204,0.0001017869,0.0007145853,0.0001472329,0.0001118872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008419783,0.0005309239,0.175797,0.0007086529,0.00005667057,0.0001085474,0.003005315,0.0006145429,0.8167144,0.0004589324,0.0001361584,0.001026935],"study_design_scores_gemma":[0.003589578,0.0004450078,0.5185115,0.0007338722,0.0004040529,0.000006843873,0.001633159,0.004544967,0.4681111,0.001158955,0.0002587389,0.0006022258],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802825,0.009708909,0.0006308486,0.00006875934,0.0000923854,0.0006140333,0.00001968877,0.00008947835,0.008493404],"genre_scores_gemma":[0.9895403,0.0007495176,0.0002207971,0.0001231317,0.00002890353,0.00007960504,0.00001633392,0.00003141654,0.009209958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3486033,"threshold_uncertainty_score":0.999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043830953710751,"score_gpt":0.31563439439114,"score_spread":0.2851960848540325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}