{"id":"W4410775242","doi":"10.1001/jamanetworkopen.2025.14278","title":"Azetukalner, a Novel K<sub>V</sub>7 Potassium Channel Opener, in Adults With Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Treatment of Major Depression","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Placebo; Major depressive disorder; Beck Depression Inventory; Hamilton Rating Scale for Depression; Hamilton Anxiety Rating Scale; Randomized controlled trial; Adverse effect; Medicine; Rating scale; Anxiety; Internal medicine; Physical therapy; Depression (economics); Psychiatry; Psychology; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007315888,0.0003178892,0.0007203124,0.0001372181,0.0001309248,0.000384931,0.0003735208,0.0005387463,0.001830557],"category_scores_gemma":[0.0006970761,0.0001757047,0.0004044624,0.0001275297,0.0002293096,0.0005246731,0.0001958735,0.0008568651,0.0002911385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544568,"about_ca_system_score_gemma":0.0003431578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002544854,"about_ca_topic_score_gemma":0.001548418,"domain_scores_codex":[0.9997739,0.0001031288,0.00002973912,0.00003499096,0.00003174674,0.00002643345],"domain_scores_gemma":[0.9997965,0.00004572675,0.00008770444,0.000006436203,0.00002515481,0.00003857036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2221063,0.01067901,0.02368257,0.01011962,0.002835192,0.0007477571,0.000439811,0.001167917,0.139529,0.0008727393,0.008591186,0.5792289],"study_design_scores_gemma":[0.3451299,0.4683092,0.1112793,0.00149327,0.00517882,0.003787477,0.0004632164,0.003649878,0.02378598,0.001261013,0.03553191,0.0001300194],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9404643,0.05251126,0.001232925,0.001719364,0.0003940309,0.0006683807,0.0005452842,0.0001188008,0.002345714],"genre_scores_gemma":[0.9754282,0.0190915,0.001781788,0.00132608,0.0002267631,0.0004116614,0.0004018866,0.000008304408,0.00132392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001830557,"threshold_uncertainty_score":0.006123781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100837982940384,"score_gpt":0.259025424062767,"score_spread":0.2489416257687286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}