{"id":"W4410776881","doi":"10.1002/hem3.70145","title":"Characterization of cancer‐associated fibroblasts and their spatial architecture reveals heterogeneity and survival associations in classic Hodgkin lymphoma","year":2025,"lang":"en","type":"article","venue":"HemaSphere","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Spinal Cord Injury BC; University Health Network","funders":"Academy of Finland; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto","keywords":"Tumor microenvironment; Stromal cell; Cancer-Associated Fibroblasts; Cancer research; Immune system; Lymphoma; Biology; Cancer; Population; Pathology; Fibroblast activation protein, alpha; Fibroblast; Nodular sclerosis; Immunology; Medicine; Internal medicine; Cell culture; Hodgkin lymphoma; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357087,0.00006438902,0.00009740542,0.0004182668,0.0001131091,0.000215357,0.00005611643,0.0001027198,0.0003926509],"category_scores_gemma":[0.00015626,0.00007782241,0.00005624404,0.0002053661,0.0001188507,0.00009482523,0.0001117962,0.0000716679,0.00008268374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023963,"about_ca_system_score_gemma":0.00005594347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006952795,"about_ca_topic_score_gemma":0.001325074,"domain_scores_codex":[0.9999328,0.00001177559,0.000004089562,0.00002436008,0.00001279667,0.00001433739],"domain_scores_gemma":[0.999923,0.0000183309,0.00002175645,0.00001002785,0.00001509052,0.00001172254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002429822,0.00001561904,0.08806993,0.00004418329,0.00001973084,0.0001541472,0.0001483449,0.0002137169,0.9053383,0.00008362634,0.00004353228,0.00562581],"study_design_scores_gemma":[0.0000118194,0.000135021,0.8497856,0.000006773752,0.00003768477,0.001492148,0.0005804395,0.003220856,0.1433219,0.000172304,0.001227209,0.000008184923],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986965,0.0002839399,0.0007770578,0.000004955401,7.619572e-7,0.000002508709,0.0001074422,0.000006651048,0.0001202244],"genre_scores_gemma":[0.9992117,0.00006713041,0.0004981147,0.00000409308,0.000001487681,0.000005035525,0.00008730134,0.000001734058,0.0001233534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006952795,"threshold_uncertainty_score":0.00138247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009133015429994338,"score_gpt":0.2374523188488286,"score_spread":0.2283193034188342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}