{"id":"W4410785517","doi":"10.1038/s44400-025-00007-1","title":"DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy","year":2025,"lang":"en","type":"article","venue":"npj Dementia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; National Institute on Drug Abuse; National Institute on Aging; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Rainwater Charitable Foundation; Global Brain Health Institute; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; Radiological Society of North America; National Institute of Biomedical Imaging and Bioengineering; Fogarty International Center; Canadian Institutes of Health Research; RSNA Research and Education Foundation; Bristol-Myers Squibb; Eli Lilly and Company; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Epigenetics; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; DNA methylation; Neuroscience; White matter; Disease; Alzheimer's disease; Biology; Psychology; Medicine; Pathology; Genetics; Magnetic resonance imaging; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006817981,0.0002545626,0.0001701537,0.0004748672,0.0001737616,0.0004061032,0.0001649545,0.0002284261,0.001044571],"category_scores_gemma":[0.001862407,0.0001246173,0.0002017157,0.0003416045,0.0001789182,0.0002436365,0.0002909232,0.0003723344,0.0001114154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740025,"about_ca_system_score_gemma":0.0002742441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002800408,"about_ca_topic_score_gemma":0.005000384,"domain_scores_codex":[0.9998524,0.00004841849,0.000008011784,0.00005747541,0.00001853432,0.00001502748],"domain_scores_gemma":[0.9995228,0.0001529991,0.0001886312,0.00005110751,0.00003432142,0.00005014874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002841261,0.00004465285,0.9767807,0.00002745648,0.0001727243,0.0000538381,0.0001582921,0.0004858674,0.009288286,0.0003246131,0.0001371711,0.01224236],"study_design_scores_gemma":[0.000005986835,0.000154539,0.9912902,0.000008401884,0.0000776798,0.0001930232,0.00007403815,0.003471805,0.003360791,0.0009209291,0.0004362689,0.00000631641],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959431,0.0003982773,0.002567376,0.00007770389,0.00000756984,0.000005515323,0.0003901238,0.00002303836,0.0005871669],"genre_scores_gemma":[0.9988257,0.00011476,0.0006567481,0.0000172909,0.00000575515,0.000004179548,0.0001185246,0.000002036161,0.0002550313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002800408,"threshold_uncertainty_score":0.005568206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008753477157440173,"score_gpt":0.2724050784432481,"score_spread":0.2636516012858079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}