{"id":"W4410794477","doi":"10.1084/jem.20241671","title":"Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Innate lymphoid cell; RAR-related orphan receptor gamma; Fibrosis; Orphan receptor; Immunology; Inflammation; Biology; Medicine; Internal medicine; Immune system; Immunity; Transcription factor; Biochemistry; FOXP3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003969315,0.000514855,0.0004257356,0.0004084969,0.0003303224,0.0007022133,0.0003216018,0.0007270139,0.001604583],"category_scores_gemma":[0.0002076099,0.0002114559,0.0004433049,0.0003167925,0.0006417725,0.0003414233,0.0003512361,0.001256848,0.0006600611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504542,"about_ca_system_score_gemma":0.0005816876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008156368,"about_ca_topic_score_gemma":0.001589461,"domain_scores_codex":[0.9995185,0.00005726323,0.0000385467,0.0001072195,0.0001418271,0.0001366151],"domain_scores_gemma":[0.9997607,0.00002849007,0.00006959155,0.00004051566,0.00003047359,0.00007025311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272092,0.0000134232,0.0001753913,0.00003664333,0.000004202407,0.00003989109,0.00001347726,0.00006095848,0.9980993,0.0001473259,0.00006319027,0.001219179],"study_design_scores_gemma":[0.00003530678,0.0001943609,0.004808408,0.00001886191,0.00002834256,0.0005743252,0.0000537715,0.0006775295,0.9864041,0.0001104576,0.00708526,0.000009285828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712531,0.007317411,0.01378617,0.0007858461,0.0001052222,0.00009216841,0.001598006,0.0004058931,0.004656156],"genre_scores_gemma":[0.9843018,0.002766985,0.006927845,0.0003612085,0.0000357142,0.0001363911,0.001042515,0.0001253836,0.004302037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001604583,"threshold_uncertainty_score":0.005367875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242558634817773,"score_gpt":0.2612631386205773,"score_spread":0.2488375522723996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}