{"id":"W4410794720","doi":"10.1073/pnas.2422126122","title":"Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Moonshot Research and Development Program; Exploratory Research for Advanced Technology; Keio University; Japan Science and Technology Agency; Tokyo University of Agriculture and Technology; University of California, San Diego; Tokyo University of Agriculture; University of Toronto; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; National Bioscience Database Center; Japan Agency for Medical Research and Development; RIKEN; University of Tokyo","keywords":"Lipotoxicity; Glycerophospholipids; Endoplasmic reticulum; Schizosaccharomyces; Pentadecanoic acid; Biology; Palmitoleic acid; Schizosaccharomyces pombe; Biochemistry; Fatty acid; Yeast; Cell biology; Chemistry; Saccharomyces cerevisiae; Linoleic acid; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446976,0.0004307761,0.000302885,0.0001502963,0.0001596643,0.0002809201,0.0001837648,0.0003043204,0.0005025695],"category_scores_gemma":[0.0001057158,0.0001779093,0.000347095,0.000171611,0.00025128,0.0001627544,0.0003854907,0.0004547774,0.0002299106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045378,"about_ca_system_score_gemma":0.0001700927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059247,"about_ca_topic_score_gemma":0.0008667991,"domain_scores_codex":[0.9998528,0.00002641248,0.00002601301,0.00003052736,0.00003900772,0.00002526659],"domain_scores_gemma":[0.9998428,0.00002993761,0.00005604887,0.0000242682,0.00001318827,0.00003370559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007329889,0.000007916402,0.00008414001,0.00001307328,0.000004487717,0.00008549388,0.00001182414,0.00006571304,0.9993219,0.00005097318,0.00001051098,0.0002706761],"study_design_scores_gemma":[0.00001149422,0.0001211573,0.001248163,0.000003763564,0.00001111777,0.0001755942,0.00003024583,0.000623908,0.9970257,0.00005033873,0.00069349,0.000004942476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951767,0.000380801,0.003143633,0.00008661362,0.0000279595,0.00002731857,0.0005108399,0.00007482428,0.0005712709],"genre_scores_gemma":[0.995003,0.0004527962,0.002251811,0.00006140502,0.000003712252,0.00002525217,0.0007099097,0.00004479528,0.001447343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059247,"threshold_uncertainty_score":0.002209544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646144034981585,"score_gpt":0.2868310411980987,"score_spread":0.2703696008482829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}