{"id":"W4410795441","doi":"10.1200/jco.2025.43.16_suppl.12060","title":"Baseline circulating growth differentiation factor-15 and the cancer phenotype in the PROACC-1 phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Cancer; Cancer cachexia; Cachexia; Oncology; Internal medicine; Phenotype; Cancer research; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00211296,0.0009834882,0.001124238,0.0002549602,0.0002727549,0.0006068621,0.0004845929,0.0007669653,0.002332378],"category_scores_gemma":[0.0008420592,0.000481852,0.0009288498,0.0002544279,0.0005309881,0.0004399096,0.0003310097,0.001541183,0.0003974423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005918257,"about_ca_system_score_gemma":0.001166455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004867031,"about_ca_topic_score_gemma":0.001464094,"domain_scores_codex":[0.9995381,0.0002573888,0.00002225019,0.00006691,0.00004549925,0.00006991521],"domain_scores_gemma":[0.99942,0.00007917078,0.0001474499,0.00004562875,0.00004727764,0.0002604241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8950819,0.02355736,0.02591057,0.0005687047,0.001128689,0.0001224312,0.0001375289,0.0008511198,0.0171758,0.0001249566,0.001903739,0.03343714],"study_design_scores_gemma":[0.4649955,0.4630333,0.06418739,0.0000465152,0.0009263218,0.0002771372,0.00005414058,0.001244758,0.002495995,0.0001483821,0.002557229,0.00003332338],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954691,0.001554934,0.0002200582,0.0001642038,0.00004238783,0.001005172,0.0007138667,0.0000263923,0.0008039051],"genre_scores_gemma":[0.99323,0.0006714939,0.0008421064,0.0003882415,0.00008413498,0.001410717,0.002251976,0.000009271168,0.001112035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332378,"threshold_uncertainty_score":0.0111745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04522568423028268,"score_gpt":0.4182877188079926,"score_spread":0.3730620345777099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}