{"id":"W4410801539","doi":"10.1182/bloodadvances.2025016141","title":"Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Heart, Lung, and Blood Institute; Alexion Pharmaceuticals; bluebird bio; Pharmacyclics; Adaptive Biotechnologies; Health Resources and Services Administration; Kite Pharma; Daiichi Sankyo Europe; Takeda Oncology; AstraZeneca; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genentech; MorphoSys; U.S. Navy; Legend Biotech; Sangamo Therapeutics; Seagen; CTI Biopharma; CareDx; BeiGene; Swedish Orphan Biovitrum; Astellas Pharma; U.S. Department of Health and Human Services; GlaxoSmithKline; Kiadis Pharma; Medac; Jazz Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; HistoGenetics; Children's Hospital of Philadelphia; Gateway for Cancer Research; Celgene; Omeros Corporation; Vertex Pharmaceuticals; U.S. Department of Defense; Sanofi; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Bristol-Myers Squibb; Cidara Therapeutics; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Amgen; Atara Biotherapeutics; Actinium Pharmaceuticals; Gilead Sciences","keywords":"Medicine; Cytokine release syndrome; Chimeric antigen receptor; Lymphoma; Internal medicine; Cumulative incidence; Incidence (geometry); CD19; Immunology; Gastroenterology; Transplantation; Antigen; Immunotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002998474,0.0002905685,0.0006473885,0.0007058127,0.0001539932,0.00005401683,0.000159545,0.0001142786,0.002247146],"category_scores_gemma":[0.00003086888,0.0002505533,0.0004885145,0.002084198,0.00005890038,0.0001755767,0.00005230116,0.0001468841,0.00004821025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009497486,"about_ca_system_score_gemma":0.0001653992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008264435,"about_ca_topic_score_gemma":0.001132477,"domain_scores_codex":[0.9979596,0.0001046037,0.0003956756,0.0006619279,0.0003556685,0.000522539],"domain_scores_gemma":[0.9986638,0.0002731357,0.0001373371,0.0006144731,0.0001765699,0.0001346357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003604097,0.005467801,0.7031714,0.0002229693,0.002649829,0.00001767667,0.0003296176,0.00001405371,0.2159147,0.0000418075,0.001701369,0.06686478],"study_design_scores_gemma":[0.01541312,0.0004749224,0.1463173,0.00006483026,0.001051299,6.176398e-7,0.00007931275,0.0001694544,0.2803166,0.0002018823,0.5555901,0.0003205657],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699175,0.01404056,0.001094316,0.000297363,0.0003929809,0.001168565,0.0001455916,0.0001472921,0.01279586],"genre_scores_gemma":[0.9167016,0.02975718,0.002904473,0.000722723,0.0005513085,0.0005070483,0.0004050252,0.00006294363,0.04838766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5568541,"threshold_uncertainty_score":0.9999947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080802239061419,"score_gpt":0.3128229019549339,"score_spread":0.3020148795643197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}