{"id":"W4410801539","doi":"10.1182/bloodadvances.2025016141","title":"Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Heart, Lung, and Blood Institute; Alexion Pharmaceuticals; bluebird bio; Pharmacyclics; Adaptive Biotechnologies; Health Resources and Services Administration; Kite Pharma; Daiichi Sankyo Europe; Takeda Oncology; AstraZeneca; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genentech; MorphoSys; U.S. Navy; Legend Biotech; Sangamo Therapeutics; Seagen; CTI Biopharma; CareDx; BeiGene; Swedish Orphan Biovitrum; Astellas Pharma; U.S. Department of Health and Human Services; GlaxoSmithKline; Kiadis Pharma; Medac; Jazz Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; HistoGenetics; Children's Hospital of Philadelphia; Gateway for Cancer Research; Celgene; Omeros Corporation; Vertex Pharmaceuticals; U.S. Department of Defense; Sanofi; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Bristol-Myers Squibb; Cidara Therapeutics; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Amgen; Atara Biotherapeutics; Actinium Pharmaceuticals; Gilead Sciences","keywords":"Medicine; Cytokine release syndrome; Chimeric antigen receptor; Lymphoma; Internal medicine; Cumulative incidence; Incidence (geometry); CD19; Immunology; Gastroenterology; Transplantation; Antigen; Immunotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267613,0.0003418055,0.0003346341,0.0008461544,0.0002882641,0.000831697,0.0003851081,0.0004110301,0.001346986],"category_scores_gemma":[0.001950811,0.0002470941,0.0006202325,0.001095182,0.0002924295,0.0004617872,0.000603489,0.0005566796,0.0004388911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007399417,"about_ca_system_score_gemma":0.0004201789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002947349,"about_ca_topic_score_gemma":0.002398279,"domain_scores_codex":[0.9989299,0.0004104174,0.0001165764,0.0001845229,0.0002053247,0.0001532245],"domain_scores_gemma":[0.9975914,0.0004138449,0.001257506,0.0002081174,0.000205157,0.0003240186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007636996,0.00009226175,0.995774,0.00003061581,0.0001096597,0.0001927497,0.00006949985,0.00008890309,0.0002346839,0.00001578358,0.0003048506,0.002323497],"study_design_scores_gemma":[0.00005702973,0.0003293354,0.9974824,0.00001418903,0.00007558225,0.0007732034,0.0001553778,0.0004473591,0.0001684982,0.00001296604,0.0004744212,0.000009685882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985083,0.00027519,0.0001106788,0.00002908325,0.000003425362,0.00001972486,0.0008010527,0.00000471828,0.0002476484],"genre_scores_gemma":[0.9980481,0.0001252076,0.00008061791,0.00003617942,0.00001317434,0.00001976418,0.001592734,0.000003046977,0.00008112795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002947349,"threshold_uncertainty_score":0.006703854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080802239061419,"score_gpt":0.3128229019549339,"score_spread":0.3020148795643197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}