{"id":"W4410802869","doi":"10.1200/jco.2025.43.16_suppl.8513","title":"Efficacy and CNS results from a randomized subset of the phase 2 SAVANNAH study comparing savolitinib (savo) + osimertinib (osi) combination with savo + placebo (PBO).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Placebo; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002330194,0.00176944,0.002007394,0.0004179227,0.0004309583,0.00076377,0.0008218893,0.001584102,0.008254995],"category_scores_gemma":[0.001782502,0.000689959,0.001924654,0.0003375956,0.0008287687,0.000999806,0.000441062,0.002599594,0.001539143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007432406,"about_ca_system_score_gemma":0.001318297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006997842,"about_ca_topic_score_gemma":0.002176752,"domain_scores_codex":[0.9991079,0.0005523222,0.00003775996,0.0001221437,0.00006349225,0.0001163433],"domain_scores_gemma":[0.998887,0.000265349,0.0002935424,0.0001004408,0.0001078578,0.0003457655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9639989,0.01179834,0.001776551,0.0003447734,0.001059352,0.00006371861,0.00004691187,0.0005088877,0.005086296,0.00009217262,0.001993317,0.01323097],"study_design_scores_gemma":[0.7810912,0.2074318,0.007784919,0.00003182283,0.0008265029,0.0001020905,0.00003316763,0.0004833791,0.0006808267,0.0002329331,0.001281411,0.00002004558],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877558,0.001486947,0.0004011952,0.0004662187,0.0001941419,0.003684137,0.003173705,0.00006829415,0.002769542],"genre_scores_gemma":[0.9825448,0.001104713,0.001264899,0.0009347795,0.0003854732,0.005846301,0.004525554,0.00003841196,0.003355035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008254995,"threshold_uncertainty_score":0.02761573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08479915726876193,"score_gpt":0.4902209261350984,"score_spread":0.4054217688663365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}