{"id":"W4410803209","doi":"10.1200/jco.2025.43.16_suppl.8611","title":"Interim results of PDL1V (PF-08046054), a vedotin-based ADC targeting PD-L1, in patients with NSCLC in a phase 1 trial.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; non-small cell lung cancer (NSCLC); Oncology; Internal medicine; Interim; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004271403,0.001199533,0.001264385,0.0003729056,0.000409414,0.001151189,0.00081366,0.001782411,0.003464355],"category_scores_gemma":[0.002392459,0.0004769199,0.001353108,0.0003209974,0.0004963474,0.0009649644,0.0003694848,0.002407969,0.001085086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001041488,"about_ca_system_score_gemma":0.001270084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006119786,"about_ca_topic_score_gemma":0.001657376,"domain_scores_codex":[0.9990149,0.0005386708,0.0000684345,0.0001118146,0.00009021017,0.0001760357],"domain_scores_gemma":[0.9986575,0.0003650861,0.0003032937,0.00008296706,0.00009743984,0.0004937975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6864073,0.02169336,0.02035722,0.001165781,0.002280417,0.0007954921,0.0003636977,0.006774809,0.02684527,0.0007368441,0.03262651,0.1999533],"study_design_scores_gemma":[0.4985718,0.4138977,0.05729937,0.0001585275,0.001821323,0.001247391,0.00008864781,0.003742304,0.007061637,0.0009454923,0.0150962,0.00006961949],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586046,0.01076034,0.001748348,0.002791743,0.0003953269,0.00404473,0.01064896,0.0003266133,0.01067944],"genre_scores_gemma":[0.9624001,0.003166243,0.00311074,0.003029573,0.0002853594,0.00381795,0.01837868,0.00008368878,0.005727693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004271403,"threshold_uncertainty_score":0.02258962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07753471214883798,"score_gpt":0.4760811882307938,"score_spread":0.3985464760819558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}