{"id":"W4410803503","doi":"10.1200/jco.2025.43.16_suppl.1037","title":"Characterization of the immune microenvironment and spatial phenotypes across HER2 subtypes in advanced or metastatic breast cancer.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Breast cancer; Metastatic breast cancer; Immune system; Tumor microenvironment; Phenotype; Cancer; Cancer research; Oncology; Internal medicine; Immunology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499505,0.0001134016,0.0002029488,0.0007964172,0.0002236905,0.000325973,0.0001706299,0.0002104761,0.001079401],"category_scores_gemma":[0.0002573139,0.0001107158,0.0001488013,0.0005725916,0.0001461152,0.0001890314,0.0002378001,0.0001684458,0.0003003012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096737,"about_ca_system_score_gemma":0.0001376973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121637,"about_ca_topic_score_gemma":0.002142758,"domain_scores_codex":[0.9998704,0.0000178812,0.00001050145,0.00003660623,0.00003485717,0.00002977582],"domain_scores_gemma":[0.9998571,0.00002537004,0.00003750843,0.0000160952,0.00003951236,0.00002436181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001245715,0.00007940434,0.3638423,0.0002968441,0.00006380488,0.0005487776,0.000338389,0.0007398129,0.605571,0.0001681279,0.0003189797,0.02678695],"study_design_scores_gemma":[0.00002082359,0.0003038018,0.9412915,0.00001439939,0.00006307958,0.002890362,0.0005421331,0.002900382,0.04940274,0.000116741,0.002445389,0.000008717338],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965687,0.0009772134,0.001371658,0.00001571067,0.000002629625,0.00002282625,0.0002976595,0.00002172192,0.0007218901],"genre_scores_gemma":[0.9971807,0.0001699814,0.001788626,0.00001439518,0.000004095604,0.00003654225,0.0004982718,0.000008723559,0.0002987623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121637,"threshold_uncertainty_score":0.003610969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07010473532947813,"score_gpt":0.4910602070998903,"score_spread":0.4209554717704121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}